Impairment of male reproductive function after sleep deprivation

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Presentation transcript:

Impairment of male reproductive function after sleep deprivation Tathiana A. Alvarenga, Ph.D., Camila Hirotsu, Ph.D., Renata Mazaro-Costa, Ph.D., Sergio Tufik, M.D., Ph.D., Monica L. Andersen, Ph.D. Fertility and Sterility Volume 103, Issue 5, Pages 1355-1362.e1 (May 2015) DOI: 10.1016/j.fertnstert.2015.02.002 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Effects of paradoxic sleep deprivation (PSD) and sleep restriction (SR) on (A) latency to intromission, (B) number of intromissions, and total numbers of (C) intromissions and (D) ejaculations. The data are expressed as mean ± SEM. (A, B) *P<.05: significant difference versus the control (CTRL) group; ¥P<.05: significant difference versus the SR group. (C, D) *P<.03: significant difference versus the CTRL group; ¥P<.002: significant difference versus the SR group. Fertility and Sterility 2015 103, 1355-1362.e1DOI: (10.1016/j.fertnstert.2015.02.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Concentrations of serum (A) testosterone and (B) progesterone and plasma (C) LH and (D) FSH in the CTRL, PSD, and SR groups. The data are expressed as mean ± SEM. *P<.01: significant difference versus the CTRL group. Abbreviations as in Figure 1. Fertility and Sterility 2015 103, 1355-1362.e1DOI: (10.1016/j.fertnstert.2015.02.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Expression of (A) endothelial nitric oxide synthase (eNOS), (B) inducible nitric oxide synthase (iNOS), (C) dimethylarginine dimethylaminohydrolase 1 (Ddah1), (D) hydroxysteroid 11b-dehydrogenase 1 (Hsd11b1), and (E) casein kinase 2b-polypeptide (Csnk2b). (A) ∗P<.05 compared with CTRL; #P<.05 compared with SR. (B) ∗P<.01 compared with CTRL; #P<.05 compared with SR. (C) No statistical differences. (D) ∗P<.05 compared with CTRL. (E) No statistical differences. The expression was measured by means of reverse-transcription quantitative polymerase chain reaction (PCR) in the testes of CTRL (non -sleep-deprived control), PSD (paradoxic sleep -deprived), and SR (sleep-restricted) rats. Fertility and Sterility 2015 103, 1355-1362.e1DOI: (10.1016/j.fertnstert.2015.02.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions