A comprehensive analysis of the COL29A1 gene does not support a role in eczema Aline Naumann, MSc, Cilla Söderhäll, PhD, Regina Fölster-Holst, MD, Hansjörg.

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Presentation transcript:

A comprehensive analysis of the COL29A1 gene does not support a role in eczema Aline Naumann, MSc, Cilla Söderhäll, PhD, Regina Fölster-Holst, MD, Hansjörg Baurecht, MSc, Viola Harde, MD, Konstanze Müller- Wehling, MD, Elke Rodríguez, PhD, Andreas Ruether, PhD, Andre Franke, PhD, Stefan Wagenpfeil, PhD, Natalija Novak, MD, Martin Mempel, MD, Behnam Naderi Kalali, PhD, Michael Allgaeuer, MSc, Jeanette Koch, MSc, Markus Gerhard, MD, Erik Melén, MD, Carl- Fredrik Wahlgren, PhD, Inger Kull, PhD, Caroline Stahl, MSc, Göran Pershagen, MD, Roger Lauener, MD, Josef Riedler, MD, Gert Doekes, PhD, Annika Scheynius, PhD, Thomas Illig, PhD, Erika von Mutius, MD, Stefan Schreiber, MD, Juha Kere, MD, Michael Kabesch, MD, Stephan Weidinger, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 5, Pages 1187-1194.e7 (May 2011) DOI: 10.1016/j.jaci.2010.12.1123 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Gene expression analysis of COL29A1 in patients with eczema (A and B, left) and healthy (C and D, right) skin. COL29A1 mRNA was detected by using the 3′UTR antisense probe (Fig 1, A and C, upper panels) and a probe generated to the sequences published in Söderhäll et al15 (Fig 1, B and D, lower panels). Both probes show an almost identical staining pattern. Stratum basale (SB), stratum spinosum (SS), stratum granulosum (SG), and stratum corneum (SC) are indicated. Journal of Allergy and Clinical Immunology 2011 127, 1187-1194.e7DOI: (10.1016/j.jaci.2010.12.1123) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

LD of the COL29A1 SNPs measured by r2 and D′ analysis with 308 population control subjects from set 1. Journal of Allergy and Clinical Immunology 2011 127, 1187-1194.e7DOI: (10.1016/j.jaci.2010.12.1123) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions