Infection outcomes in patients with common variable immunodeficiency disorders: Relationship to immunoglobulin therapy over 22 years Mary Lucas, BSc,

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Presentation transcript:

Infection outcomes in patients with common variable immunodeficiency disorders: Relationship to immunoglobulin therapy over 22 years Mary Lucas, BSc, Martin Lee, BA, PhD, Jenny Lortan, MBBS, PhD, Eduardo Lopez-Granados, MD, PhD, Siraj Misbah, MBBS, Helen Chapel, MA, MD Journal of Allergy and Clinical Immunology Volume 125, Issue 6, Pages 1354-1360.e4 (June 2010) DOI: 10.1016/j.jaci.2010.02.040 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Number, type, and severity of infections in patients with CVIDs over the 8891 months of analyzed data. Red bars are the proportion of each infection type that was classified as severe. GI, Gastrointestinal infection; LRTI, lower respiratory tract infection; URTI, upper respiratory tract infection; UTI, urinary tract infection. Journal of Allergy and Clinical Immunology 2010 125, 1354-1360.e4DOI: (10.1016/j.jaci.2010.02.040) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Mean trough IgG levels to keep individual patients infection- free. Mean IgG trough levels are shown relative to the total number of patients with CVIDs or XLA. Red bars represent patients with CVIDs; blue bars represent patients with XLA. A, Periods using a threshold of infection score at ≤4.5 per year. B, Periods using a threshold of infection score at ≤2.5 per year. C, Periods using a threshold of infection score at 0 per year. Journal of Allergy and Clinical Immunology 2010 125, 1354-1360.e4DOI: (10.1016/j.jaci.2010.02.040) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Distribution of mean trough IgG levels (A), mean replacement dose of immunoglobulin (B), and mean infection number per patient-year (C) for each patient-period across 3 decades. Blue bars, 1980 to 1989; red bars, 1990 to 1999; yellow bars, 2000 to 2007. Each bar represents the number of specific periods in that decade. Journal of Allergy and Clinical Immunology 2010 125, 1354-1360.e4DOI: (10.1016/j.jaci.2010.02.040) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Correlation between trough serum IgG level and replacement immunoglobulin dose in patients without (A) and with (B) bronchiectasis for each given period of stable serum IgG concentration during follow-up. Red line represents the regression coefficient for that data set. Journal of Allergy and Clinical Immunology 2010 125, 1354-1360.e4DOI: (10.1016/j.jaci.2010.02.040) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions