Fig. 4. The predicted protein domains in sma

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Fig. 4. The predicted protein domains in sma Fig. 4. The predicted protein domains in sma.(A) Predicted protein domains in the sma suppressor gene determined using Motif Scan (Pagni et al., 2007) are shown with amino acid positions listed next to each. The predicted protein domains in sma.(A) Predicted protein domains in the sma suppressor gene determined using Motif Scan (Pagni et al., 2007) are shown with amino acid positions listed next to each. The regions are: SAP for SAP DNA-binding domain, GBD-FH3 for G-protein-binding formin homology 3, PTEN for phosphatase tensin domain, and NLS for nuclear localization signal. (B) ClustalW2 alignment of the predicted SAP domain from Sma with SAP domain sequences from H. sapiens (Myocardin accession no. AAV33439, and SARNP accession no. NP_149073.1) and from S. cerevisiae (an E3 ligase, accession no. 2RNN). Characteristics of the SAP domains are colored as described previously (Aravind and Koonin, 2000) and represent a 90% consensus among the initial SAP domains that they identified: hydrophobic or aliphatic residues (YFWLIVMAC) are in yellow, polar residues (STQNEDRKH) are in purple, bulky residues (KREQWFYLMI) are in gray, an absolutely conserved glycine (G) is green and a highly conserved lysine (K) is red. Two amphipathic helices were determined for the Sma protein using the PredictProtein program and are overlined. They match perfectly with the positions of the amphipathic helices in the SAP domain alignment characterized previously (Aravind and Koonin, 2000). Jessica S. Kelsey, and Daphne D. Blumberg Biology Open 2013;2:396-406 © 2013. Published by The Company of Biologists Ltd