Bleeding Complications and Blood Product Utilization With Left Ventricular Assist Device Implantation Justin M. Schaffer, MS, George J. Arnaoutakis,

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Bleeding Complications and Blood Product Utilization With Left Ventricular Assist Device Implantation Justin M. Schaffer, MS, George J. Arnaoutakis, MD, Jeremiah G. Allen, MD, Eric S. Weiss, MD, Nishant D. Patel, MD, Stuart D. Russell, MD, Ashish S. Shah, MD, John V. Conte, MD The Annals of Thoracic Surgery Volume 91, Issue 3, Pages 740-749 (March 2011) DOI: 10.1016/j.athoracsur.2010.11.007 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Box plot of daily product transfusion requirements for the first postoperative week according to (A) total products, (B) packed red blood cells, (C) fresh frozen plasma, and (D) platelets. (POD = postoperative day.) The Annals of Thoracic Surgery 2011 91, 740-749DOI: (10.1016/j.athoracsur.2010.11.007) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Box plot of daily chest tube output for the first postoperative week. (POD = postoperative day.) The Annals of Thoracic Surgery 2011 91, 740-749DOI: (10.1016/j.athoracsur.2010.11.007) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Breakdown of our CF patient population by closure approach (primary closure vs delayed sternal closure), with delineation of subsequent bleeding complications. The Annals of Thoracic Surgery 2011 91, 740-749DOI: (10.1016/j.athoracsur.2010.11.007) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 (A) Histogram of operative pRBCs transfused. (grey column = < 5 units pRBC transfused [p = 49]; black column = ≥ 5 units pRBC transfused [n = 37]). (B) Kaplan-Meier survival curve by strata of intraoperative blood transfusion requirements groups. (— = < 5 units pRBC transfused; — = ≥ 5 units pRBC transfused; p > 0.001, by log-rank test.) The Annals of Thoracic Surgery 2011 91, 740-749DOI: (10.1016/j.athoracsur.2010.11.007) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Kaplan-Meier estimate of freedom from gastrointestinal bleeding. The Annals of Thoracic Surgery 2011 91, 740-749DOI: (10.1016/j.athoracsur.2010.11.007) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions