Volume 18, Issue 3, Pages (March 2003)

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Volume 18, Issue 3, Pages 441-452 (March 2003) Nonpathogenic SIV Infection of Sooty Mangabeys Is Characterized by Limited Bystander Immunopathology Despite Chronic High-Level Viremia Guido Silvestri, Donald L. Sodora, Richard A. Koup, Mirko Paiardini, Shawn P. O'Neil, Harold M. McClure, Silvija I. Staprans, Mark B. Feinberg Immunity Volume 18, Issue 3, Pages 441-452 (March 2003) DOI: 10.1016/S1074-7613(03)00060-8 Copyright © 2003 Cell Press Terms and Conditions

Figure 1 Lack of Correlation between CD4+ T Cell Counts and SIV-Plasma Viremia in 18 Naturally SIV-Infected SMs Best-fit line is shown. Immunity 2003 18, 441-452DOI: (10.1016/S1074-7613(03)00060-8) Copyright © 2003 Cell Press Terms and Conditions

Figure 2 Bone Marrow and Lymph Node Morphology in SIV-Infected and Uninfected SMs Histological features of a BM biopsy in an SIV-infected SM (HE 40×) (A) and an uninfected SM (B). Histological features of an inguinal LN in an SIV-infected SM (HE staining, 40×) (C) and of an uninfected animal (D). In situ detection of apoptotic cells using the TUNEL assay in a LN section from an SIV-infected SM (E) and an uninfected animal (F). Immunity 2003 18, 441-452DOI: (10.1016/S1074-7613(03)00060-8) Copyright © 2003 Cell Press Terms and Conditions

Figure 3 TREC Levels in Sorted CD4+ and CD8+ T Cells from SIV-Infected and Uninfected Infected SMs Isolated CD4+ (left panel, 17 animals per group) and CD8+ (right panel, 19 animals per group) T cells were assessed for TREC levels. TREC levels are plotted against the age, with best-fit lines shown (solid line for uninfected, dashed line for infected SMs). Immunity 2003 18, 441-452DOI: (10.1016/S1074-7613(03)00060-8) Copyright © 2003 Cell Press Terms and Conditions

Figure 4 Levels of Baseline, Spontaneous, and Activation Induced-Apoptosis in CD4+ and CD8+ T Cells from SIV-Infected and Uninfected SMs Were Measured Using Annexin V and 7AAD Staining and Flow Cytometric Analysis (A) The positive staining for Annexin V and 7AAD induced by the proapoptotic agent Campthotecin. (B) The low levels of baseline (time 0) and spontaneous (after 48 hr without any stimulus) in both SIV-infected and uninfected SMs. (C) The lack of statistically significant differences between SIV-infected and uninfected SMs in the rates of baseline, spontaneous, and activation-induced (following 48 hr of ConA stimulation) apoptosis, measured as rates of Annexin V-positive cells, in either CD4+ or CD8+ T cells. Immunity 2003 18, 441-452DOI: (10.1016/S1074-7613(03)00060-8) Copyright © 2003 Cell Press Terms and Conditions

Figure 5 Expression of the Ki67 Proliferation Marker in PB-, LN-, and BM-Derived CD4+ T Cells from SIV-Infected (SIV+) and Uninfected (SIV−) SMs Percentage of proliferating cells are shown with each bar representing an individual animal. The analysis was completed for the following numbers of animals: SIV-infected (29 for PB; 10 for LN and BM); SIV-uninfected (18 for PB, 8 for LN and BM). Immunity 2003 18, 441-452DOI: (10.1016/S1074-7613(03)00060-8) Copyright © 2003 Cell Press Terms and Conditions

Figure 6 Decreased CD4+ T Cell Counts in SIV-Infected SMs Are Correlated with Increased Levels of T Cell Activation Inverse correlations between CD4+ T cell counts and frequencies of CD8+DR+ T cells ([A], 19 animals), CD4+ T cell counts and CD95 expression (MFI) on CD4+ T cells ([B], 13 animals), and a direct correlation between CD95 expression (MFI) on CD4+ T cells and TNF-α production by CD8+ T cells ([C], 13 animals) is seen in SIV-infected SMs. Best-fit lines are shown. Immunity 2003 18, 441-452DOI: (10.1016/S1074-7613(03)00060-8) Copyright © 2003 Cell Press Terms and Conditions