Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline Joseph P. Mathew, MD, Henry M. Rinder, MD, Brian.

Slides:

Advertisements

Similar presentations

Giant Transdiaphragmatic Intercostal Hernia

Advertisements

Robert L. Smith, MD, Morley A. Herbert, PhD, Todd M

Diaphragmatic Defect Complicating Peritoneal Dialysis

The Annals of Thoracic Surgery

Mina L. Boutrous, MD, Rana O. Afifi, MD, Hazim J. Safi, MD, Anthony L

Total Arch Replacement Under Normothermic Beating Heart Surgery

Gal Levy, MD, Mark A. Cordes, MD, Alexander S. Farivar, MD, Ralph W

Shangyi Ji, MD, Jianan Yang, MD, Xiaoqing Ye, MD, Xiaolei Wang, MD

Benson Bertheau Roe, MD, July 7, 1918–August 6, 2012

Denton A. Cooley, August 22, 1920, to November 18, 2016

Sivelestat Attenuates Lung Injury in Surgery for Congenital Heart Disease With Pulmonary Hypertension Norikazu Nomura, MD, PhD, Miki Asano, MD, PhD,

Mark D. Iannettoni, MD, William R. Lynch, MD, Kalpaj R

Simple Index to Predict Likelihood of Skilled Nursing Facility Admission After Coronary Artery Bypass Grafting Among Older Patients David C. Chang, PhD,

Surgical Resection of a Giant Coronary Aneurysm

Public policy and the practicing physician

Total Arterial Revascularization: A Superior Strategy for Diabetic Patients Who Require Coronary Surgery James Tatoulis, MD, FRACS, Rochelle Wynne, PhD,

Origins of the Cardiothoracic Surgery Network (CTSNet)

James D. St. Louis, MD The Annals of Thoracic Surgery

Who Do You Say You Are? The Annals of Thoracic Surgery

Which Patients Benefit From Stentless Aortic Valve Replacement?

Congenital Absence of Bilateral Common Carotid Arteries

The “Double-Valve” Sign in Acute Type A Aortic Dissection

Use of Amiodarone After Major Lung Resection

Kuthan Kavakli, MD, Deniz Dogan, MD, Sedat Gurkok

Anomalous Origin of Left Pulmonary Artery From Left Subclavian Artery

Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass

Coronary Artery Bypass Grafting With Single Cross-Clamp Results in Fewer Persistent Neuropsychological Deficits Than Multiple Clamp or Off-Pump Coronary.

Hybrid Management of a Giant Left Main Coronary Artery Aneurysm

The Annals of Thoracic Surgery

Percutaneous Transcatheter Closure of the Aortic Valve

Gerald G.R. Sng, Cameron D. Wright, MD The Annals of Thoracic Surgery

Redo Aortic Valve Replacement in Children

Embolized Methyl Methacrylate to the Right Atrium After Kyphoplasty

Michael J. Wolf, MD, Kirk R. Kanter, MD, Paul M. Kirshbom, MD, Brian E

Editorial Board, January 2010

Bradford B. Smith, MD, Matthew A

Severe Two-Vessel Ostial Stenosis of the Main Coronary Arteries in a Patient With Transposition of the Great Arteries After an Arterial Switch Operation

Daniel R. Wong, MD, MPH, Joseph S

Completely Thrombosed Tricuspid Pouch Mimicking a Cardiac Tumor

An Unusual Cause of Hemoptysis in a Young Woman

The Unifocal Bilateral Bidirectional Cavopulmonary Anastomosis

Christine S. Rinder, MD, Michael J. Smith, PhD, Henry M

Brian M. Cardis, MD, Derek A. Fyfe, MD, PhD, William T. Mahle, MD

Joseph Galea, MD, FRCS, Alexander Manché, MPhil, FRCS

Specialty Training and Mortality After Esophageal Cancer Resection

Neurocognitive Function and Cerebral Emboli: Randomized Study of On-Pump Versus Off-Pump Coronary Artery Bypass Surgery Reza Motallebzadeh, MRCS, J.

The Annals of Thoracic Surgery

Massimo Meco, MD, Silvia Cirri, MD The Annals of Thoracic Surgery

Invited Commentary The Annals of Thoracic Surgery

Functional and Physiologic Results of Video-Assisted Thoracoscopic Diaphragm Plication in Adult Patients With Unilateral Diaphragm Paralysis Richard.

Robert Lee Replogle, September 30, 1931–May 9, 2016

Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery.

Pulmonary Embolectomy for Acute Massive Pulmonary Embolism

The American Board of Thoracic Surgery: Update

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Comparing Aortic Root Replacements: Porcine Bioroots Versus Pericardial Versus Mechanical Composite Roots: Hemodynamic and Ventricular Remodeling at Greater.

Experience With Bovine Pericardium for the Reconstruction of the Aortic Arch in Patients Undergoing a Norwood Procedure Victor O. Morell, MD, Peter A.

Dumbor L. Ngaage, MD, FRCS (C-Th), Michael E. Cowen, FRCS

Mark I. Block, MD The Annals of Thoracic Surgery

Lobectomy Versus Limited Resection in T1N0 Lung Cancer

The Impact of New Technology on Cardiothoracic Surgical Practice

Slide Tracheoplasty in Infants and Children: Risk Factors for Prolonged Postoperative Ventilatory Support Peter B. Manning, MD, Michael J. Rutter, MD,

Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury Christine S Rinder, MD, Manuel Fontes, MD,

Faisal G. Bakaeen, MD, Joseph S. Coselli, MD, Scott A

Aortic Valve Function After Bicuspidization of the Unicuspid Aortic Valve Diana Aicher, MD, Moritz Bewarder, Michael Kindermann, MD, Hashim Abdul-Khalique,

Harvey Edward Garrett, MD, Bradley A. Wolf, MD

J. Alberto Lopez, MD The Annals of Thoracic Surgery

David S. Mulder, MD The Annals of Thoracic Surgery

Michelle C. Wallace, MD, James Jaggers, MD, Jennifer S

How I Teach Hemi-Arch Replacement

Presentation transcript:

Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline Joseph P. Mathew, MD, Henry M. Rinder, MD, Brian R. Smith, MD, Mark F. Newman, MD, Christine S. Rinder, MD The Annals of Thoracic Surgery Volume 81, Issue 5, Pages 1644-1649 (May 2006) DOI: 10.1016/j.athoracsur.2005.12.070 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Jugular-arterial (J-A) platelet activation gradient in patients with and without cognitive deficit. The gradient of P-selectin+ platelets was compared in 24 cognitive deficit (CD) patients versus 57 patients with no CD at the following time points: baseline (BASE), immediately before aortic cross-clamp release (aXCR), 5 minutes after aortic XCR (5min pXCR), and at the end of surgery (endOR). At the 5 minutes after XCR time point, patients with a CD had a significantly greater J-A platelet activation gradient (*p = 0.048). The Annals of Thoracic Surgery 2006 81, 1644-1649DOI: (10.1016/j.athoracsur.2005.12.070) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Jugular-arterial (JUG-ART) gradient for leukocyte-platelet conjugates in patients with and without cognitive deficit (CD). The gradient of (A) monocytes with bound platelets and (B) neutrophils (polymorphonuclear leukocytes) with bound platelets was compared in patients with and without CD at the times identified in Fig 1. The leukocyte-platelet conjugate gradient did not differ between patient groups at any time point (p > 0.05) for both (A) monocyte-platelet and (B) polymorphonuclear leukocytes-platelet. (BASE = baseline; aXCR = immediately before aortic cross-clamp release; 5min pXCR = 5 minutes after aortic XCR; endOR = at the end of surgery.) The Annals of Thoracic Surgery 2006 81, 1644-1649DOI: (10.1016/j.athoracsur.2005.12.070) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions