Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs. Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs.

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Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs. Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs. (A) Current-voltage (I-V) relationship of L-type calcium current (ICa) (above) and voltage clamp protocol used (below). P<0.05 from −10 mV to 60 mV (WT-CMs versus HCMT-CMs, one-way ANOVA, post hoc Tukey test). P<0.05 from 10 mV to 60 mV (WT-CMs versus HCMM-CMs, one-way ANOVA, post hoc Tukey test). (B) I-V relationship of transient outward potassium current (Ito) (above) and voltage clamp protocol used (below). P<0.05 from 30 mV to 70 mV (WT-CMs versus HCMT-CMs and WT-CMs versus HCMM-CMs; one-way ANOVA, post hoc Tukey test). (C) I-V relationship of inward rectifier outward current (IK1) (above) and voltage clamp protocol used (below) (ns at all test potentials, WT-CMs versus HCMT-CMs and WT-CMs versus HCMM-CMs; one-way ANOVA, post hoc Tukey test). Data are mean±s.e.m. Values inside parentheses represent the number of CMs used. Chandra Prajapati et al. Dis. Model. Mech. 2018;11:dmm032896 © 2018. Published by The Company of Biologists Ltd