John Koreth, Edwin P. Alyea, William J. Murphy, Lisbeth A. Welniak

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Presentation transcript:

Proteasome Inhibition and Allogeneic Hematopoietic Stem Cell Transplantation: A Review John Koreth, Edwin P. Alyea, William J. Murphy, Lisbeth A. Welniak Biology of Blood and Marrow Transplantation Volume 15, Issue 12, Pages 1502-1512 (December 2009) DOI: 10.1016/j.bbmt.2009.07.016 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Potential mode of action in bortezomib mediated antitumor responses. Bortezomib may have a negative impact on the growth and spread of cancer cells through multiple mechanisms including direct induction of apoptosis, sensitization to killing by CD8+ cytotoxic T cells and NK cells, and through reduction of inflammation resulting in decreased metastasis. Biology of Blood and Marrow Transplantation 2009 15, 1502-1512DOI: (10.1016/j.bbmt.2009.07.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions