Fig. 5 Quantitative assessment of the efficacy of the tissue-engineered implant to heal the TMJ disc defect. Quantitative assessment of the efficacy of.

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Fig. 5 Quantitative assessment of the efficacy of the tissue-engineered implant to heal the TMJ disc defect. Quantitative assessment of the efficacy of the tissue-engineered implant to heal the TMJ disc defect. (A) Histological appearance of a defect treated with tissue-engineered implant versus untreated discs. Square brackets indicate the defect location. Scale bar, 2 mm. (B) Percent of the combined pouch and fenestration defect perimeter closure indicative of the extent of healing. (C) Young’s modulus values representing the tensile stiffness of the repair tissue that formed in the discs treated with tissue-engineered implant versus untreated discs. (D) Osteoarthritis (OA) scores derived from evaluation of the mandibular heads in implant-treated groups versus untreated groups to measure TMJ degeneration. For all graphs, bars indicate means ± SD (P < 0.05). Student’s t test was used with n = 6, and all data were taken at 8 weeks after implantation. Natalia Vapniarsky et al., Sci Transl Med 2018;10:eaaq1802 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works