Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years Meryam El Issaoui, M.D., Veronica.

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Presentation transcript:

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years Meryam El Issaoui, M.D., Veronica Giorgione, M.D., Linn S. Mamsen, M.Sc., Catherine Rechnitzer, M.D., Niels Birkebæk, M.D., Niels Clausen, M.D., Thomas W. Kelsey, Ph.D., Claus Yding Andersen, D.M.Sc. Fertility and Sterility Volume 106, Issue 7, Pages 1757-1762.e1 (December 2016) DOI: 10.1016/j.fertnstert.2016.09.001 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Follicular density in ovarian cortex. No statistically significant difference was found in follicular density in the ovarian cortex from patients who did or did not receive first-line antineoplastic treatment. The lines are quadratic best-fit to the data for the two groups. Fertility and Sterility 2016 106, 1757-1762.e1DOI: (10.1016/j.fertnstert.2016.09.001) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Ovarian volume. Ovarian volume was statistically significantly reduced by previous antineoplastic treatment as compared with those who did not receive pretreatment (P<.05). The lines are quadratic best-fit to the data for the two groups. Fertility and Sterility 2016 106, 1757-1762.e1DOI: (10.1016/j.fertnstert.2016.09.001) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Number of ovarian cortex chips cryopreserved to preserve fertility. The number of cryopreserved pieces of cortex was statistically significantly lower in patients who underwent cancer treatment before removal of one ovary compared to those who did not receive pretreatment (P<.05). Fertility and Sterility 2016 106, 1757-1762.e1DOI: (10.1016/j.fertnstert.2016.09.001) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions