Analysis of PD-L1 tumour-cell membrane staining concordance between PD-L1 immunohistochemistry 22C3 and 28-8 assays across all matched tumour biopsies.

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Presentation transcript:

Analysis of PD-L1 tumour-cell membrane staining concordance between PD-L1 immunohistochemistry 22C3 and 28-8 assays across all matched tumour biopsies or biopsies with a confirmed lung cancer diagnosis. Analysis of PD-L1 tumour-cell membrane staining concordance between PD-L1 immunohistochemistry 22C3 and 28-8 assays across all matched tumour biopsies or biopsies with a confirmed lung cancer diagnosis. (A) Bubble plot of matched tumour biopsies stained with PD-L1 immunohistochemistry 28-8 and 22C3 assays against the identity line (orange). Node size is proportional to the number of measurements. (B) Bland-Altman plot of the difference in the percentage of stained tumour-cell membrane. Dashed lines represent the lower 2.5th and upper 97.5th percentiles for the difference between both readings; solid lines represent the mean difference. Bland-Altman analysis visualises the mean difference in percentage of tumour-cell membranes against the average PD-L1 expression of the two assays. PD-L1, programmed death ligand 1. Cory Batenchuk et al. J Clin Pathol 2018;71:1078-1083 Copyright © by the BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved.