Small dose of exogenous surfactant combined with partial liquid ventilation in experimental acute lung injury: effects on gas exchange, haemodynamics,

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Small dose of exogenous surfactant combined with partial liquid ventilation in experimental acute lung injury: effects on gas exchange, haemodynamics, lung mechanics, and lung pathology S. Wolf, H. Lohbrunner, T. Busch, A. Sterner‐Kock, M. Deja, A. Sarrafzadeh, U. Neumann, U. Kaisers British Journal of Anaesthesia Volume 87, Issue 4, Pages 593-601 (October 2001) DOI: 10.1093/bja/87.4.593 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Time course of arterial oxygen tension (PaO2) during baseline (pre‐lavage), after induction of ALI (post‐lavage), and for 6 h thereafter, in controls (n=8 at ALI; four pigs died before 6 h after ALI), in pigs treated with surfactant (Curosurf®) after induction of ALI (SURF‐group) (n=8 pigs, none died), and in pigs treated with surfactant (Curosurf®) followed by PLV with 30 ml kg–1 of perfluorocarbon (PF 5080) after induction of ALI (SURF‐PLV‐group) (n=8 pigs, none died). Data are mean (sem). Intergroup comparison: controls vs SURF‐PLV‐group and controls vs SURF‐group: *P<0.05, and SURF‐PLV‐group vs SURF‐group: †P<0.05 (Kruskal–Wallis ANOVA and post hoc Dunn’s test). Intragroup comparison: data measured after induction of ALI vs data obtained at hourly intervals thereafter: ‡P<0.05 (Friedman test and post hoc Dunn’s test). British Journal of Anaesthesia 2001 87, 593-601DOI: (10.1093/bja/87.4.593) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Time course of intrapulmonary shunting (Q˙s/Q˙t) during baseline (pre‐lavage), after induction of ALI (post‐lavage), and for 6 h thereafter, in controls (n=8 at ALI; four pigs died before 6 h after ALI), in pigs treated with surfactant (Curosurf®) after induction of ALI (SURF‐group) (n=8 pigs, none died), and in pigs treated with a single surfactant (Curosurf®) followed by PLV with 30 ml kg–1 of perfluorocarbon (PF 5080) after induction of ALI (SURF‐PLV‐group) (n=8 pigs, none died). Data are mean (sem). Intergroup comparison: controls vs SURF‐PLV‐group and controls vs SURF‐group: *P<0.05, and SURF‐PLV‐group vs SURF‐group: †P<0.05 (Kruskal–Wallis ANOVA and post hoc Dunn’s test). Intragroup comparison: data measured after induction of ALI vs data obtained at hourly intervals thereafter: ‡P<0.05 (Friedman test and post hoc Dunn’s test). British Journal of Anaesthesia 2001 87, 593-601DOI: (10.1093/bja/87.4.593) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 Time course of MPAP during baseline (pre‐lavage), after induction of ALI (post‐lavage), and for 6 h thereafter, in controls (n=8 at ALI; four pigs died before 6 h after ALI), in pigs treated with surfactant (Curosurf®) after induction of ALI (SURF‐group) (n=8 pigs, none died), and in pigs treated with surfactant (Curosurf®) followed by PLV with 30 ml kg–1 of perfluorocarbon (PF 5080) after induction of ALI (SURF‐PLV‐group) (n=8 pigs, none died). Data are mean (sem). Intergroup comparison: controls vs SURF‐PLV‐group and controls vs SURF‐group: *P<0.05, and SURF‐PLV‐group vs SURF‐group: †P<0.05 (Kruskal–Wallis ANOVA and post hoc Dunn’s test). Intragroup comparison: data measured after induction of ALI vs data obtained at hourly intervals thereafter: ‡P<0.05 (Friedman test and post hoc Dunn’s test). British Journal of Anaesthesia 2001 87, 593-601DOI: (10.1093/bja/87.4.593) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 4 Time course of static compliance of the respiratory system (CRS) during baseline (pre‐lavage), after induction of ALI (post‐lavage), and for 6 h thereafter, in controls (n=8 at ALI; four pigs died before 6 h after ALI), in pigs treated with surfactant (Curosurf®) after induction of ALI (SURF‐group) (n=8 pigs, none died), and in pigs treated with surfactant (Curosurf®) followed by PLV with 30 ml kg–1 of perfluorocarbons (PF 5080) after induction of ALI (SURF‐PLV‐group) (n=8 pigs, none died). Data are mean (sem). Intergroup comparison: controls vs SURF‐PLV‐group: *P<0.05 (Kruskal–Wallis ANOVA and post hoc Dunn’s test). British Journal of Anaesthesia 2001 87, 593-601DOI: (10.1093/bja/87.4.593) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions