Relationship between selected metabolic parameters and the primary composite end point. Relationship between selected metabolic parameters and the primary composite end point. A: Percentage of increased risk for the primary composite end point associated with elevated values of selected baseline metabolic factors. B–D: Hazard ratios by quartile of those selected metabolic parameters that were statistically significant: total cholesterol (tC) (B), LDL cholesterol (C), and triglycerides (TG) (D). *P < 0.05; **P < 0.001. Gerald B. Appel et al. Dia Care 2003;26:1402-1407 ©2003 by American Diabetes Association