Mohamad Irani, M.D., Zaher Merhi, M.D. Fertility and Sterility

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Presentation transcript:

Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review Mohamad Irani, M.D., Zaher Merhi, M.D. Fertility and Sterility Volume 102, Issue 2, Pages 460-468.e3 (August 2014) DOI: 10.1016/j.fertnstert.2014.04.046 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Effect of vitamin D on serum antimüllerian hormone (AMH) and AMH/AMH receptor II gene expression. PCOS = polycystic ovary syndrome. Fertility and Sterility 2014 102, 460-468.e3DOI: (10.1016/j.fertnstert.2014.04.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Role of vitamin D in human luteinized granulosa cells. Vitamin D down-regulates FSH receptor (FSHR) and antimüllerian hormone (AMH) receptor II (AMHR-II) mRNA levels. It also decreases Smad 1/5/8 phosphorylation and nuclear translocation. Additionally, vitamin D induces 3-beta-hydroxysteroid dehydrogenase (3β-HSD) mRNA expression and increases progesterone production and release. Fertility and Sterility 2014 102, 460-468.e3DOI: (10.1016/j.fertnstert.2014.04.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Association of vitamin D deficiency with factors related to ovulatory dysfunction in polycystic ovary syndrome (PCOS). Fertility and Sterility 2014 102, 460-468.e3DOI: (10.1016/j.fertnstert.2014.04.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Summary of the origin and function of vitamin D. Reprinted by permission from Dr. Frauke von Versen–Höynck: Grundmann M, von Versen–Höynck F. Vitamin D—roles in women's reproductive health? Reprod Biol Endocrinol 2011; 9:146. Fertility and Sterility 2014 102, 460-468.e3DOI: (10.1016/j.fertnstert.2014.04.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Data search strategy. Fertility and Sterility 2014 102, 460-468.e3DOI: (10.1016/j.fertnstert.2014.04.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Antimüllerian hormone (AMH) inhibits FSH-induced follicular growth in a paracrine fashion. Fertility and Sterility 2014 102, 460-468.e3DOI: (10.1016/j.fertnstert.2014.04.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions