Effects of insulin administration in streptozotocin-treated mice.

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Effects of insulin administration in streptozotocin-treated mice. Effects of insulin administration in streptozotocin-treated mice. A: Mice were treated with streptozotocin, and after 3 days, insulin was administered (5 IU/kg i.p.; 0, 5, 15, and 30 min), and protein extracts of the cerebral cortex were immunoblotted for site-selective tau phosphorylation and total tau. B: Insulin was administered to control or streptozotocin-treated mice, and PP2A activity was measured. Quantitative values are means ± SE from four mice per group. *P < 0.05 compared with control values. Buffie J. Clodfelder-Miller et al. Diabetes 2006;55:3320-3325 ©2006 by American Diabetes Association