The mutants exhibit congenital hypothyroidism.

Slides:

Advertisements

Similar presentations

Mitochondria localize to both the front and the rear of neutrophils.

Advertisements

Ocular defects produced by Daam1 mutation and in combination with diabetes. Ocular defects produced by Daam1 mutation and in combination with diabetes.

The pathophysiological processes linked to kidney disease.

Abnormalities of the aortic arch in Hectd1opm/opm mutant embryos.

mTOR downregulation, but not autophagy, reduces VAP(P58S) aggregation.

SNARE motif sequence alignment of GOSR2 and its yeast ortholog, Bos1.

BTN1 mRNA level in response to extracellular pH determined by comparative RT2PCR. BTN1mRNA level in response to extracellular pH determined by comparative.

Localisation of epithelial markers in mMEC cultures.

A highly conserved six-amino-acid region in the C-terminal CT domain of MARCH8 is responsible for its ability to downregulate TfR. A highly conserved six-amino-acid.

Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/−

Alterations in Notch signaling affect the frequency of intermediate and main IHBD branches. Alterations in Notch signaling affect the frequency of intermediate.

Fig. 6. Cross-section of the stomach wall and spiral intestine of the embryo, stained with PAS. (A) Surface of the stomach wall (SW) and ingested material.

OA is found in the central and peripheral nervous systems.

Tbx1 regulates the Mef2c AHF enhancer in vivo.

Embryonic corneal defects in E18.5 AP-2β NCC KO mutant embryos.

Smo deficiency in the renal stroma is dependent on GLI3R.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Fig. 1. Mitochondrial internalization in cardiomyocytes.

Concentration of biomarkers of haemostasis.

Fig. 3. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Inactivation.

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Scanning EM shows cilia abnormalities in the neural tube.

Hipk induces cell spreading.

Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

Latency to onset of Stage III behavioral seizure activity.

Obesity affected the metabolic response to stroke.

Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

Fgfr3 mutation is not the sole driver of tumorigenesis in the bladder.

Effects of LMHFV and oestrogen (E2) supplementation on bone healing in OVX mice 21 days after osteotomy. Effects of LMHFV and oestrogen (E2) supplementation.

Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W embryos at E16.5. Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W.

Hipk induces overgrowths in Drosophila imaginal discs.

Treatment of HCMT-CMs with bisoprolol.

Detection of nuclear foci by FISH on frozen sections of diaphragm muscle prepared from 2-month-old DMSXL mice. Detection of nuclear foci by FISH on frozen.

Elevated expression of vegfaa in hemangiosarcoma.

Delayed formation of sensory hair cells in dlx3b/4b-deficient embryos

Morphological differences in newborn (P0) mice carrying mutations associated with three FGFR2-related craniosynostosis syndromes and their unaffected littermates.

Overexpression of individual signaling pathway components does not phenocopy the cell-spreading phenotype induced by elevated Hipk. Overexpression of individual.

The effect of TDP-43A315T expression on dendrite spine development.

The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.

Variations in tissue stiffness.

Abnormalities that are combined with or are indicators for life-threatening defects (Sc4). Abnormalities that are combined with or are indicators for life-threatening.

The effect of TDP-43A315T expression at the synapse.

Elevation of ERK downstream signaling is associated with tumor formation in the bladder and in papilloma formation. Elevation of ERK downstream signaling.

Rgs16::GFP expression in pancreatic neoplasia.

Otitis media in Edaraddswh/swh rats is associated with smaller auditory-tube submucosal glands (SMGs). Otitis media in Edaraddswh/swh rats is associated.

Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.

col22a1−/− mutant adults exhibit hemorrhages.

Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P

Abnormally low or high Tj expression causes a decrease in DEcad expression and shg enhancer activity. Abnormally low or high Tj expression causes a decrease.

Injection volume influences tumor architecture and desmoplastic response. Injection volume influences tumor architecture and desmoplastic response. (A)

Induction of liver tumors in TO(Myc) fish.

Dose-response curves and images for confirmed screening hits.

Tumor location determines response to intravenous FOLFIRINOX chemotherapy. Tumor location determines response to intravenous FOLFIRINOX chemotherapy. (A)

Attenuated STM expression in drn and drnl mutants.

Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.

Food-additive exposure reduces adult fly survival under some feeding conditions. Food-additive exposure reduces adult fly survival under some feeding conditions.

Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants.

V-ATPase and proteins involved in late endosomal protein sorting are required for efficient utilization of LDs during growth resumption. V-ATPase and proteins.

Ibm1 and edm2 mutants generate more stomatal divisions in the leaf epidermis. ibm1 and edm2 mutants generate more stomatal divisions in the leaf epidermis.

Examples of tumors represented in Tp53Δ11/Δ11 and Tp53Δ11/+ rats.

ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)

Peroxisome speeds were slower in patient and control cells.

Accelerated retinal degeneration after systemic depletion of circulating BM-derived microglia in rd7/rd7;Tg/Tg mice. Accelerated retinal degeneration after.

The vps13 mutants are hypersensitive to SDS but cell wall integrity is not compromised. The vps13 mutants are hypersensitive to SDS but cell wall integrity.

Effects of paclitaxel and vinblastine.

Disruption of the tubule formation by immortalized cells during nephrogenesis in vitro. Disruption of the tubule formation by immortalized cells during.

Graphical representation of pain levels versus time postinjury, annotated across control, persistently hypersensitive genotypes and diabetic conditions,

2DG suppresses of lamellipodia and filopodia and causes disorganization of F-actin filaments in murine endothelial cells. 2DG suppresses of lamellipodia.

Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

Presentation transcript:

The mutants exhibit congenital hypothyroidism. The mutants exhibit congenital hypothyroidism. (A) The mutation was located in the peroxidase-like domain. (B) Histological section analysis indicated abnormalities in the thyroid and pituitary glands, which are associated with thyroid hormone production. Scale bars: 50 μm. (C) Measurement of thyroid hormones in the peripheral blood showed that the thyroid hormones of T3 and T4 were significantly decreased in mutant pigs, whereas TSH was markedly elevated (mean±s.d.; Student's t-test; **P<0.01; n=6 in each group). AA, amino acids. Chunwei Cao et al. Dis. Model. Mech. 2019;12:dmm036616 © 2019. Published by The Company of Biologists Ltd