Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study Mònica Guxens, MD, MPH, PhD, Agnes M.M. Sonnenschein–van.

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Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study Mònica Guxens, MD, MPH, PhD, Agnes M.M. Sonnenschein–van der Voort, MSc, Henning Tiemeier, MD, PhD, Albert Hofman, MD, PhD, Jordi Sunyer, MD, PhD, Johan C. de Jongste, MD, PhD, Vincent W.V. Jaddoe, MD, PhD, Liesbeth Duijts, MD, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 1, Pages 59-67.e12 (January 2014) DOI: 10.1016/j.jaci.2013.04.044 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Associations of maternal (A) and paternal (B) psychological distress during pregnancy with wheezing from 1 to 4 years. Odds ratios (95% CIs) from generalized estimating equation models represent the odds of wheezing for the children of mothers or fathers with psychological distress (no, yes). P value trend (p-trend) represents the linear trend per unit increase on the psychological distress scales. Models were adjusted for maternal age, body mass index, smoking during pregnancy, educational level, ethnicity, and parity; parental history of asthma or atopy and pet keeping; and children's sex, preterm birth, birth weight, breast-feeding, day care attendance, secondhand smoke at home, eczema, and lower respiratory tract infections. *Models additionally adjusted for maternal psychological distress during pregnancy. Journal of Allergy and Clinical Immunology 2014 133, 59-67.e12DOI: (10.1016/j.jaci.2013.04.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Flowchart of participants in the study. Journal of Allergy and Clinical Immunology 2014 133, 59-67.e12DOI: (10.1016/j.jaci.2013.04.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Unadjusted association between maternal (A) and paternal (B) psychological distress during pregnancy and wheezing from 1 to 4 years. Journal of Allergy and Clinical Immunology 2014 133, 59-67.e12DOI: (10.1016/j.jaci.2013.04.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Complete case analysis: adjusted associations of maternal (A) and paternal (B) psychological distress during pregnancy with wheezing from 1 to 4 years. Journal of Allergy and Clinical Immunology 2014 133, 59-67.e12DOI: (10.1016/j.jaci.2013.04.044) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions