Figure 1. Time–kill curves of M. abscessus CIP

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Figure 1. Time–kill curves of M. abscessus CIP 104536 Figure 1. Time–kill curves of M. abscessus CIP 104536. (a) Dose–response of M. abscessus CIP 104536 against a ... Figure 1. Time–kill curves of M. abscessus CIP 104536. (a) Dose–response of M. abscessus CIP 104536 against a concentration range of bedaquiline (BDQ) in CAMHB; the MIC was 0.25 mg/L. (a) Combination time–kill curves of M. abscessus with bedaquiline and clofazimine (CZM) and in combination in M7H9; MICs were 1 mg/L for bedaquiline and 1 mg/L for clofazimine. (c) Percentage of the 3×MIC bedaquiline-resistant population of (b). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) J Antimicrob Chemother, Volume 74, Issue 4, 10 January 2019, Pages 935–943, https://doi.org/10.1093/jac/dky526 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2. Time–kill curves of M. avium ATCC 700898 Figure 2. Time–kill curves of M. avium ATCC 700898. (a) Dose–response of M. avium ATCC 700898 against a concentration ... Figure 2. Time–kill curves of M. avium ATCC 700898. (a) Dose–response of M. avium ATCC 700898 against a concentration range of bedaquiline (BDQ) in CAMHB; the MIC was 0.06 mg/L. (b) Combination time–kill curves of M. avium with bedaquiline and clarithromycin (CLR) and in combination in CAMHB; MICs were 0.06 mg/L for bedaquiline and 2 mg/L for clarithromycin. (c) Percentage of the 3×MIC clarithromycin-resistant population of (b). (d) Percentage of the 3×MIC bedaquiline-resistant population of (b). (e) Combination time–kill curves of M. avium with bedaquiline and clofazimine (CZM) and in combination in M7H9; MICs were 0.25 mg/L for bedaquiline and 0.25 mg/L for clofazimine. (f) Percentage of the 3×MIC bedaquiline-resistant population of (e). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) J Antimicrob Chemother, Volume 74, Issue 4, 10 January 2019, Pages 935–943, https://doi.org/10.1093/jac/dky526 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3. Fitted concentration–response curves of M Figure 3. Fitted concentration–response curves of M. abscessus (a) and M. avium (b) with bedaquiline. (a) Curve fitting ... Figure 3. Fitted concentration–response curves of M. abscessus (a) and M. avium (b) with bedaquiline. (a) Curve fitting of M. abscessus dose–response against bedaquiline. E<sub>max</sub> was determined to be 26.71 log<sub>10</sub> cfu/mL×day, EC<sub>50</sub> is 2.45×MIC and the Hill slope was 2.26. (b) Curve fitting of M. avium dose–response against bedaquiline. E<sub>max</sub> was determined to be 50.34 log<sub>10</sub> cfu/mL×day, EC<sub>50</sub> is 0.31×MIC and the Hill slope was 1.73. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) J Antimicrob Chemother, Volume 74, Issue 4, 10 January 2019, Pages 935–943, https://doi.org/10.1093/jac/dky526 The content of this slide may be subject to copyright: please see the slide notes for details.