Effects of the components of hormone therapy on matrix metalloproteinases in breast- cancer cells: an in vitro study  Maher A. Abdallah, M.D., Huda I. Abdullah, M.S., Steven Kang, M.D., Douglas D. Taylor, Ph.D., Steven T. Nakajima, M.D., Cicek Gercel- Taylor, Ph.D.  Fertility and Sterility  Volume 87, Issue 4, Pages 978-981 (April 2007) DOI: 10.1016/j.fertnstert.2006.08.091 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Effect of E2 and Eq combined with the progestogens norethinderone acetate (N), medroxyprogesterone (M), and progesterone (P) on MMP-2 (A) and MMP-9 (B) in T47D and MCF-7 cells. Cells were incubated with 10 nM of E2 or Eq combined with 10 nM of the respective progestogens for 48 hours. Data are presented as the average of three zymography experiments analyzed by densitometry, and presented as a fraction of control ± SEM. *P<.05 compared to controls. Abdallah. HT induces MMPs in breast cancer cells. Fertil Steril 2007. Fertility and Sterility 2007 87, 978-981DOI: (10.1016/j.fertnstert.2006.08.091) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions