Manhattan plot for the association between COPD and DNA methylation in never smokers (left) and current smokers (right). Manhattan plot for the association.

Slides:



Advertisements
Similar presentations
Chart 1: Oxygen prescription for acutely hypoxaemic patients in hospital. Chart 1: Oxygen prescription for acutely hypoxaemic patients in hospital. ABG,
Advertisements

Lungs transplanted between 4 and 8 AM have a higher incidence of PGD
Flow diagram of participants included in the survey. aResponse rate
The significantly different metabolites between the systemic inflammatory response syndrome SIRS (n=15) and sepsis (n=35) groups (A); the sepsis (n=10)
Association between average daily intake of alcoholic drinks and risk of active tuberculosis using restricted cubic spline regression with four knots*.
Mean changes in the Short Form-36 subscales from baseline values for combined pulmonary fibrosis and emphysema (CPFE) (n=16), and chronic obstructive pulmonary.
Relationship between the change in a) ventilatory and b) cerebrovascular responses in older healthy subjects (Older) and chronic obstructive pulmonary.
Image of the form used by ambulance officers to triage patients with an exacerbation of chronic obstructive pulmonary disease (COPD).  GP, general practitioner;
Patients with exacerbations of chronic obstructive pulmonary disease admitted to hospital according to the day of the week (A), and presenting to the emergency.
Distribution of lower extremity artery disease (LEAD) Fontaine stages over the combined chronic obstructive pulmonary disease (COPD) Global Initiative.
Monthly admissions for chronic obstructive pulmonary disease (COPD) to Christchurch Hospital. Monthly admissions for chronic obstructive pulmonary disease.
The top 25 analytes by relevant q-value differentially expressed in HIV with COPD. The top number is m/z and the bottom number is RT. Y-axis is intensity.
Venn diagram showing the overlap between the various chronic obstructive pulmonary disease (COPD) diagnoses: self-reported physician-diagnosed, fixed ratio.
Association of sputum colour score with (A) total cell counts; (B) neutrophil proportion; (C) neutrophil number and (D) CXCL-8 concentration. Association.
Serum levels of angiopoietin-like protein 4 (ANGPTL4) according to patients with chronic obstructive pulmonary disease and controls without any lung disease.
Change from baseline in (A) E-RS total score and (B) E-RS cough and sputum domain score over the study period in ATTAIN and the active-comparator study.
(A) Refined profile principal component analysis loading weights plot was used to derive insight into possible association of biomarkers. (A) Refined profile.
A white elephant or the elephant in the room
(A, B) Airway circularity (Cr), (C, D) normalised wall thickness (WT
Comparison of the age-associated prevalence (y axis) in the Catalan Healthcare Surveillance System (CHSS) and Medicare datasets of selected disease groups.
Bland-Altman plots comparing intraobserver PWV repeatability.
Change from baseline in the severity of night-time cough and the frequency of night-time sputum production at week 12 in ACCORD COPD I.17 Data are reported.
(A) Percentage of emphysematous lung (Emph%), (B) functional small airway disease (fSAD%), (C) tissue fraction at inspiration (βtissue), (D) fractional.
Prevalence (x axis) of disease groups (DGs) (y axis) in the population of Medicare (light cyan) and Catalan Healthcare Surveillance System (CHSS) (light.
(A) Temporal order of pairwise diagnoses in patients with chronic obstructive pulmonary disease (COPD). (A) Temporal order of pairwise diagnoses in patients.
Patients’ pathways to Accident and Emergency (A&E)
Incidence of choking in London, UK, by gender per 1000 population by age group. Incidence of choking in London, UK, by gender per 1000 population by age.
Peripheral blood eosinophil levels based on a threshold of (A) 150 cells/μL, patients not randomised to inhaled corticosteroids (ICS)-containing treatment.
Use of medication among chronic obstructive pulmonary disease (COPD) cases by age and place of residence among 1586 COPD cases. The dark grey bar represents.
a) Mortality per time point (p<0
Prevalence of chronic obstructive pulmonary disease (COPD) defined by different criteria by age, and place of residence. The dark grey bar represents ‘rural’
Illustration of model 2, with CFQ-R total score as the outcome.
Time to death from diabetes diagnosis for propensity-matched sample adjusted for age, gender, race, and other conditions. Time to death from diabetes diagnosis.
Forest plots for randomised and cluster randomised controlled trials from Cochrane review Biomarkers as point-of-care tests to guide prescription of antibiotics.
Kaplan–Meier curves for the time until myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-positive conversion (A: MPO-ANCA, B: proteinase 3.
Changes in median exhaled CO levels from baseline to 12 weeks in quitters (n=183) and continuous smokers (n=94). Changes in median exhaled CO levels from.
Changes in St. George's Respiratory Questionnaire (SGRQ) scores from baseline to 12 weeks for total samples (n=277), quitters (n=183) and continuous smokers.
Slope of FEV1 by age at enzyme replacement therapy (ERT) initiation FEV1 z-score slope (y-axis) by age categorised in three groups (red, ERT initiation 
Comparative receiver operating characteristic (ROC) curves and the area under the curve (AUC) in association with 30-day mortality for severity scores.
Receiver operating characteristic curves (ROC) for the metabolites between the systemic inflammatory response syndrome (n=15) and sepsis (n=35) groups.
Worse eDiary scores are associated the more rescue inhaler usage and reduced step counts over both an individual day and 3-week summary period. Worse eDiary.
Plot of change in incremental shuttle walk test following pulmonary rehabilitation according to ACE (insertion/deletion) polymorphism. Plot of change in.
Changes in 6 min walk distance (6MWD) for combined pulmonary fibrosis and emphysema (CPFE) (n=15), and chronic obstructive pulmonary disease (COPD) (n=37).
Prevalence of air flow obstruction (age-adjusted) by (A) lower limit of normal of forced expiratory ratio versus self-reported doctor diagnosis and (B)
Manhattan plots for GWAS of LD50, µg/ml survival, 0
Scatter plot of body mass index (BMI) versus forced expiratory volume in the first second (FEV1), and linear correlation lines for normal spirometry and.
A) 8-isoprostane levels in exhaled breath condensate in smokers with chronic obstructive pulmonary disease (COPD). *: p
Revised taxonomy of integrated palliative care initiatives in Europe (changes are highlighted in green; CHF, chronic heart failure; COPD, chronic obstructive.
Screening test accuracy of the final risk score at a threshold of ≥2
Distribution of patients in the first- or second-year follow-up according to the number of acute exacerbations of chronic obstructive pulmonary disease.
Spider diagram showing choking incident count by day of week and hour of day. Spider diagram showing choking incident count by day of week and hour of.
Reclined functional residual capacity (FRC) predicts cough inspired volume, which in turn predicts cough flow. Reclined functional residual capacity (FRC)
Illustration of model 1, with CFQ-R total score as the outcome.
HFNC off is compared with HFNC 30 L/min and HFNC 50 L/min for tidal volume. HFNC off is compared with HFNC 30 L/min and HFNC 50 L/min for tidal volume.
Schematic diagram of the shared subgroups between asthma and chronic obstructive pulmonary disease (COPD). Schematic diagram of the shared subgroups between.
Weekly bronchitis cases (circles, left hand axis) and particulate matter with a diameter below 10 µ (PM10) (crosses, right hand axis), with smoothed curves.
Taxonomy applied on a specialised homecare palliative care initiative in Germany (blue arrows; CHF, chronic heart failure; COPD, chronic obstructive pulmonary.
COPD Action Plan adherence.
The telesystem. The telesystem. Patients received regular automated calls from a computer-linked telesystem. Patients could also directly contact the telesystem.
Cox regression analysis of the proportion of patients remaining in remission during azathioprine treatment related to minimum observed white blood cell.
Vitamin D3 increased ASL antimicrobial activity in non-smokers.
Prevalence of chronic obstructive pulmonary disease (COPD) defined by different criteria by region. The dark grey bar represents ‘symptom-based COPD’,
Composite PRM image (PRM∑) in two exemplar patients with tobacco smoke (TS) exposure and chronic obstructive pulmonary disease (COPD) (top left) and biomass.
Chronic obstructive pulmonary disease (COPD) prevalence (postbronchodilator FEV1/FVC (forced expiratory volume in 1 s/forced vital capacity)
Comparison of exhaled H2O2 values in chronic obstructive pulmonary disease (COPD) patients (n=12) and control group (n=9). a) Raw ambient air concentrations.
Stacked bar charts for key predictor variables (representativeness of SLS COPD). Stacked bar charts for key predictor variables (representativeness of.
Frequency distribution histograms of the Exacerbations of Chronic Pulmonary Disease Tool (EXACT) total, the COPD Assessment Test (CAT), the St George’s.
Receiver operating characteristic (ROC) curves for Saint George’s Respiratory Questionnaire (SGRQ) category scores predicting chronic obstructive pulmonary.
The natural history of chronic obstructive pulmonary disease (COPD) is a mixture of the natural history of the various phenotypes making up the umbrella.
Change in COPD (chronic obstructive pulmonary disease) assessment test (CAT) score after pulmonary rehabilitation corresponding to different responses.
Presentation transcript:

Manhattan plot for the association between COPD and DNA methylation in never smokers (left) and current smokers (right). Manhattan plot for the association between COPD and DNA methylation in never smokers (left) and current smokers (right). Robust logistic regression analysis was performed, adjusted for age, gender, pack years, batch effects and white blood cell composition. Vertical line indicates genome wide significance (p<1.19×10−7). COPD, chronic obstructive pulmonary disease. Maaike de Vries et al. BMJ Open Resp Res 2018;5:e000282 ©2018 by British Thoracic Society