Exogenous nitric oxide modulates the systemic inflammatory response and improves kidney function after risk-situation abdominal aortic surgery Francisco.

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Exogenous nitric oxide modulates the systemic inflammatory response and improves kidney function after risk-situation abdominal aortic surgery Francisco S. Lozano, MD, PhD, José M. López-Novoa, MD, PhD, José M. Rodriguez, MD, PhD, Marcello B. Barros, MD, Francisco J. García-Criado, MD, PhD, Juan L. Nicolás, MD, Alvaro Parreño, MD, José Revilla, MD, Alberto Gómez-Alonso, MD, PhD Journal of Vascular Surgery Volume 42, Issue 1, Pages 129-139 (July 2005) DOI: 10.1016/j.jvs.2005.03.030 Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 1 Time course of serum creatinine in the experimental groups. Suprarenal aortic clamping (C) induces an increase in serum creatinine levels (*P < .01), which return to normal levels by day 7. With associated hemorrhage (H+C), apart from being more marked (**P < .001), this increase persists at day 7 (P < .05). Exogenous NO administration (groups C+NO and H+C+NO) reduces these increases (†P < .01) except on day 7, both groups behaving in a similar way to the sham group. Note: * and ** vs. sham; † vs C and H+C, respectively. Journal of Vascular Surgery 2005 42, 129-139DOI: (10.1016/j.jvs.2005.03.030) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 2 Inducible nitric oxide synthase (iNOS) expression in the kidney 72 hours after surgery. Top, A representative Western blot for iNOS. Bottom, mean ± standard error of the mean of five different blots. Groups C (*P < .01) and H+C (**P < .001) show increased iNOS levels with respect to the sham animals, but the values return to normal in the two assay groups (C+NO and H+C+NO) (P = no significance vs sham). In both assay groups, iNOS expression decreases significantly with respect to their respective controls: C (‡P < .01) and H+C (†P < .01). Note: * and ** vs sham; ‡ vs C; † vs H+C. Journal of Vascular Surgery 2005 42, 129-139DOI: (10.1016/j.jvs.2005.03.030) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 3 Activation of nuclear factor-κB (NF-κB) in the kidney 48 hours after surgery. Groups C (*P < .05) and H+C (**P < .01) show increased NF-κB levels with respect to the sham animals, and these are normalized in the two assay groups (C+NO and H+C+NO) (P = no significance vs sham). The hemorrhage in the H+C group significantly increases the expression of the factor with respect to clamping alone (§P < .01). Expression is significantly reduced in both the assay groups in comparison with their respective controls C (‡P < .05) and H+C (†P < .01). Note: * and ** vs sham; § and ‡ vs C; † vs H+C. Journal of Vascular Surgery 2005 42, 129-139DOI: (10.1016/j.jvs.2005.03.030) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions