Induction of apoptosis by nelfinavir and bortezomib

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Induction of apoptosis by nelfinavir and bortezomib Supplemental Figure 4 Induction of apoptosis by nelfinavir and bortezomib Amo-1 cells were treated with nelfinavir (nelfi) 10-20 mM alone or in combination with bortezomib (bzb) 20 nM and the surface expression of annexin V and 7-AAD were quantified by flow cytometry. The numbers in the individual quadrants represent the relative fraction of cells in each quadrant as % of total cells. bzb untreated 7.8 18.5 2.0 6.0 22.4 15.7 nelfi 10µM 7.0 25.8 4.8 nelfi 20 µM 14.0 34.5 3.1 bzb+nelfi10µM 14.6 27.5 3.0 bzb+nelfi 20µM 17.1 32.0 3.8 7-AAD annexin V