Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

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Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. (A) Comparison of Myc-induced zebrafish liver cancer with seven mouse models. Hierarchical clustering of the seven mouse models were adapted from a previous publication (Lee et al., 2004). The level of similarity of Myc-induced zebrafish liver cancer and different mouse models are shown in different colors, with red indicating positive correlation and green indicating negative correlation. (B) Heat map showing expression patterns of 125 Myc upregulated genes (top) and 16 target genes (bottom) in different human conditions. The scale bar represents up- (red) or down- (blue) regulation of genes with fold change in log2 ratio. Zhen Li et al. Dis. Model. Mech. 2013;6:414-423 © 2013. Published by The Company of Biologists Ltd