Identifying the heterogeneity of young adult rhinitis through cluster analysis in the Isle of Wight birth cohort Ramesh J. Kurukulaaratchy, DM, FRCP,

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Presentation transcript:

Identifying the heterogeneity of young adult rhinitis through cluster analysis in the Isle of Wight birth cohort Ramesh J. Kurukulaaratchy, DM, FRCP, Hongmei Zhang, PhD, Veeresh Patil, MRCP, Abid Raza, PhD, Wilfried Karmaus, MD, DrMed, MPH, Susan Ewart, DVM, PhD, S. Hasan Arshad, DM, FRCP Journal of Allergy and Clinical Immunology Volume 135, Issue 1, Pages 143-150.e7 (January 2015) DOI: 10.1016/j.jaci.2014.06.017 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Persistent rhinitis symptom frequency for the rhinitis clusters. The prevalence of persistent rhinitis symptoms (>4 days/week and >4 weeks in the past year) is shown. Error bars are SEs. Cluster 1, Moderate childhood-onset-rhinitis; cluster 2, mild adolescence-onset female rhinitis; cluster 3, severe earliest-onset rhinitis with asthma; cluster 4, moderate childhood-onset male rhinitis with asthma. Journal of Allergy and Clinical Immunology 2015 135, 143-150.e7DOI: (10.1016/j.jaci.2014.06.017) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Age of asthma versus rhinitis onset for patients with dual disease in the rhinitis clusters. Cluster 1, Moderate childhood-onset-rhinitis; cluster 2, mild adolescence-onset female rhinitis; cluster 3, severe earliest-onset rhinitis with asthma; cluster 4, moderate childhood-onset male rhinitis with asthma. Journal of Allergy and Clinical Immunology 2015 135, 143-150.e7DOI: (10.1016/j.jaci.2014.06.017) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Rhinitis morbidity and prevalence of asthma for 18-year rhinitis clusters. The size of the spheres is proportionate to the prevalence of clusters. Asthma prevalence at 18yr, Ever had asthma and either of wheezing in the last 12 months or asthma treatment in the last 12 months. A lot of impairment of activity due to rhinitis at 18yr, Percentage within each cluster answering yes to this question. Journal of Allergy and Clinical Immunology 2015 135, 143-150.e7DOI: (10.1016/j.jaci.2014.06.017) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions