Fig. 3. The effect of VRC01 infusion on virus load in plasma and blood CD4 T cells during ART. The effect of VRC01 infusion on virus load in plasma and.

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Measuring the latent HIV Reservoir

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Measuring the latent HIV Reservoir

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Fig. 3. The effect of VRC01 infusion on virus load in plasma and blood CD4 T cells during ART. The effect of VRC01 infusion on virus load in plasma and blood CD4 T cells during ART. (A) Plasma viremia was measured by SCA (n = 5). (B and C) The percentage of total peripheral CD4 T cells in each sample containing total HIV DNA (B) or integrated HIV DNA (C) was measured by quantitative polymerase chain reaction (qPCR) (n = 6). (D) The percentage of cells inducibly transcribing multiply spliced tat/rev RNA was quantified by TILDA (n = 6). (E) The percentage of cells producing replication-competent HIV after in vitro stimulation was measured by quantitative coculture (n = 4). (F to K) The percentages of sorted CM and EM CD4 T cell subsets containing total HIV DNA were measured by fluorescence-assisted clonal amplification (FCA) (F and G) (n = 6). Copies of unspliced gag RNA (H and I) and multiply spliced rev RNA (J and K) per HIV DNA copy in CM (H and J) and EM (I and K) CD4 T cell subsets were measured by qRT-PCR (n = 6). Vertical dashed lines in each plot indicate the days of the two VRC01 infusions. Participants who received VRC01 doses of 20 mg/kg (n = 3) are indicated with circular symbols and solid lines; those who received 40 mg/kg (n = 3) are indicated with triangular symbols and dashed lines. Where samples yielded values below the assay detection limit, this detection limit is plotted as an open symbol. Rebecca M. Lynch et al., Sci Transl Med 2015;7:319ra206 Copyright © 2015, American Association for the Advancement of Science