Sensory feedback and perception.

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Sensory feedback and perception. Sensory feedback and perception. (A) Median and ulnar nerve sites on the amputee’s residual limb and the corresponding regions of activation in the phantom hand due to TENS. Psychophysical experiments quantified the perception of the nerve stimulation including (B) detection and (C) discrete frequency discrimination thresholds. In both cases, the stimulation amplitude was held at 1.4 mA. (D) The perception of the nerve stimulation was largely a tactile pressure on the activated sites of the phantom hand, although sensations of electrical tingling also occurred. (E) The quantification of pain from nerve stimulation shows that the most noxious sensation is perceived at higher stimulation pulse widths with frequencies in the range of 10 to 20 Hz. (F) Contralateral somatosensory cortex activation during nerve stimulation shows relevant cortical representation of sensory perception in the amputee participant (movie S1). Luke E. Osborn et al. Sci. Robotics 2018;3:eaat3818 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works