A: Relative risk of experiencing one or more hypoglycemic events per participant at any time (24 h) and during the night (0000–0559 h) for Gla-300 vs. A: Relative risk of experiencing one or more hypoglycemic events per participant at any time (24 h) and during the night (0000–0559 h) for Gla-300 vs. Gla-100 during the 6-month treatment period. B: Cumulative mean number of nocturnal confirmed (≤3.9 mmol/L [≤70 mg/dL]) or severe hypoglycemic events per participant during the 6-month treatment period. C: Estimated number of confirmed (≤3.9 mmol/L [≤70 mg/dL]) or severe events per participant-year from week 9 to month 6 according to HbA1c at month 6. D: Cumulative mean number of confirmed (≤3.9 mmol/L [≤70 mg/dL]) or severe hypoglycemic events per participant at any time (24 h) during the 6-month treatment period. E: Percentage of participants with one or more confirmed or severe hypoglycemic events by time of day during the 6-month treatment period. Data for safety population. Hannele Yki-Järvinen et al. Dia Care 2014;37:3235-3243 ©2014 by American Diabetes Association