Defects in neuronal cell migration from the SVZ

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Defects in neuronal cell migration from the SVZ Defects in neuronal cell migration from the SVZ. (A) Migration of neuronal precursors along the rostral migratory stream (RMS). Defects in neuronal cell migration from the SVZ. (A) Migration of neuronal precursors along the rostral migratory stream (RMS). Schematic illustrates the normal migration of cells born at the SVZ along the RMS to reach the olfactory bulbs (OB), where they differentiate into interneurons. This process is disrupted in bdKO mice, in which cells accumulate at the SVZ. (B) BrdU labeling shows impaired migration of neuronal cells from the SVZ along the RMS. Sagittal brain sections stained with anti-BrdU antibody reveal the accumulation of BrdU-positive cells in the SVZ of MRTF bdKO brains as compared with normal migration in the control sections. (C) Cell counts for neurons at the olfactory bulb in MRTF bdKO mice. Counts of the number of cells per field (40 fields total from four sections) reveal a significant difference between the number of neurons in the olfactory bulb of bdKO and control mice (*P<0.0001). (D) H&E-stained brain sections at the level of the olfactory bulb show a decrease in the number of interneurons in the bdKO mice as compared with their control littermates. Scale bars: 200 μm. Mayssa H. Mokalled et al. Development 2010;137:2365-2374 © 2010.