Volume 72, Issue 4, Pages (August 2007)

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Volume 72, Issue 4, Pages 387-388 (August 2007) In vivo two-photon fluorescence microscopy opens a new area for investigation of the excretion of cationic drugs in the kidney H. Koepsell Kidney International Volume 72, Issue 4, Pages 387-388 (August 2007) DOI: 10.1038/sj.ki.5002239 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Excretion and reabsorption of organic cations in rat kidney. (a) Transporters in the basolateral and luminal membrane of proximal tubular cells that mediate secretion (red arrows) and reabsorption (blue arrows) of organic cations. The individual transporters are described in the text. (b) Visualization of secretion and reabsorption of intravenously injected ASP+ in rat kidney. In vivo fluorescence in the outer cortex is shown that was observed 6–7 seconds or 10–15 seconds after injection of ASP+. Fluorescence in blood vessels and tubular cells is shown in red. Very weak fluorescence in tubular lumina is shown in light pink. Strong fluorescence on basolateral membranes of early proximal tubules and distal tubules is shown in yellow, whereas strong fluorescence at the luminal membrane of late proximal tubules is shown in green. The dashed line indicates the border of fluorescence excitation. Kidney International 2007 72, 387-388DOI: (10.1038/sj.ki.5002239) Copyright © 2007 International Society of Nephrology Terms and Conditions