Macrophage differentiation and their role in tumourigenesis

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Macrophage differentiation and their role in tumourigenesis Figure 1 from Aras and Zaidi British Journal of Cancer Advance Online Publication (2017) 117, 1583-1591 doi:10.1038/bjc.2017.356 Several approaches exist to target Eph receptors. Kinase inactivating strategies include kinase inhibitors or blocking peptides or antibodies. Kinase activating strategies include ligand stimulation, activating antibodies or ligand peptide mimetics Strategies to deliver toxic payloads following receptor activation and internalisation include coupling of cytotoxic agents or radionuclides to Eph monoclonal antibodies. © 2017 The Author(s).