Fig. 4. (A) The effect of PGE2 on cAMP release

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Fig. 4. (A) The effect of PGE2 on cAMP release Fig. 4. (A) The effect of PGE2 on cAMP release. PGE2 stimulated cAMP release in a dose-dependent manner. (B) The effect of forskolin on VEGF production. Forskolin increased VEGF production in a dose-dependent manner. *P<0.05 and †P<0.01 vs. the control. (C) The effect of cAMP on VEGF production via the EP4 receptor. CAY10580 increased cAMP release. When AH 23848 was added before the treatment of PGE2, cAMP level was significantly decreased. The means±SE of data from six experiments are shown. *P<0.05 vs. control and †P<0.05 vs. PGE2. cAMP, cyclic adenosine monophosphate; PGE2, prostaglandin E2; VEGF, vascular endothelial growth factor; EP, E-prostanoid; CAY10580, EP4 receptor agonist; AH23848, EP4 receptor antagonist; Forskolin, cAMP activator; SE, standard error. Fig. 4. (A) The effect of PGE2 on cAMP release. PGE2 stimulated cAMP release in a dose-dependent manner. (B) The effect of forskolin on VEGF production. Forskolin increased VEGF production in a dose-dependent manner. *P<0.05 and †P<0.01 vs. the control. (C) The effect of cAMP on VEGF production via the EP4 receptor. CAY10580 increased cAMP release. When AH . . . Allergy Asthma Immunol Res. 2013 Jul;5(4):224-231. http://dx.doi.org/10.4168/aair.2013.5.4.224