Pigmented mammary Paget disease positive for melanocytic markers

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Presentation transcript:

Pigmented mammary Paget disease positive for melanocytic markers Joon Soo Park, MD, Min Jung Lee, MD, Hyun Chung, MD, Jae Bok Park, MD, Dong Hoon Shin, MD Journal of the American Academy of Dermatology Volume 65, Issue 1, Pages 247-249 (July 2011) DOI: 10.1016/j.jaad.2009.12.059 Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical appearance: hyperpigmented macule on left nipple. Journal of the American Academy of Dermatology 2011 65, 247-249DOI: (10.1016/j.jaad.2009.12.059) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, Lesion involves the epidermis. In the upper dermis, there is moderate infiltration of lymphocytes (hematoxylin-eosin stain, ×40). Inset: Tumor cells with atypical nuclei are present in the underlying lactiferous duct and mitoses are frequent. B, Paget cells expressed immunoreactivity for cytokeratin 7. Inset: Tumor cells in lactiferous ducts are positive for cytokeratin 7. C, Immunostaining for HMB-45 demonstrated pigment within the cytoplasm of Paget cells. Inset: Tumor cells in lactiferous ducts are negative for HMB-45. D, Immunohistochemical staining of Paget cells is positive for S-100. Inset: S-100 positive Paget cell. Journal of the American Academy of Dermatology 2011 65, 247-249DOI: (10.1016/j.jaad.2009.12.059) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions