CXCR5+/+ TFH cells are essential for the generation of LCMV-neutralizing antibodies and clearance of a persistent LCMV infection. CXCR5+/+ TFH cells are.

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CXCR5+/+ TFH cells are essential for the generation of LCMV-neutralizing antibodies and clearance of a persistent LCMV infection. CXCR5+/+ TFH cells are essential for the generation of LCMV-neutralizing antibodies and clearance of a persistent LCMV infection. (A) Neutralization of LCMV by serum of untreated or DTx-treated control, CXCR5−/−, and M25 chimeras. Pooled data of three independent experiments, n = 3 to 5 mice per group. Error bars represent means ± SD. (B) Viral titers in the spleen of naïve C57BL/6 mice infected with clone 13 together with either naïve (gray, −DTx) or serum derived from untreated (−DTx), DTx-treated (+DTx) control, or CXCR5−/− chimeras at d4 pi. Representative data of two independent experiments, n = 3. (C) Viral titers in blood at d20 and d70 pi in untreated and DTx-treated control, CXCR5−/−, and M25 chimeras. (D) Viral titers in the spleen at d100 pi in untreated and DTx-treated control, CXCR5−/−, and M25 chimeras. (C and D) Pooled data of three independent experiments, n = 3 to 5 mice per group. Mann-Whitney U test was used for statistical analysis, P > 0.05. Ute Greczmiel et al. Sci. Immunol. 2017;2:eaam8686 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works