Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea Shin Fukudo, Motoko Ida, Hiraku Akiho, Yoshihiro.

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Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea Shin Fukudo, Motoko Ida, Hiraku Akiho, Yoshihiro Nakashima, Kei Matsueda Clinical Gastroenterology and Hepatology Volume 12, Issue 6, Pages 953-959.e4 (June 2014) DOI: 10.1016/j.cgh.2013.11.024 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Flowchart of patient progress throughout the study. Reasons for dropping out of the study are shown. Clinical Gastroenterology and Hepatology 2014 12, 953-959.e4DOI: (10.1016/j.cgh.2013.11.024) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Monthly responder rates of improvement in stool consistency. Column height: responder rate (%). Error bar: 95% CI. P values were calculated by using the χ2 test. Clinical Gastroenterology and Hepatology 2014 12, 953-959.e4DOI: (10.1016/j.cgh.2013.11.024) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Secondary end points. (A) Monthly responder rates for relief of overall IBS symptoms. (B) Monthly responder rates for relief of abdominal pain/discomfort. P values were calculated by using the χ2 test. (C) Weekly changes in BSFS scores. Line graph: means ± SD. *P < .01, **P < .001 compared with placebo. Clinical Gastroenterology and Hepatology 2014 12, 953-959.e4DOI: (10.1016/j.cgh.2013.11.024) Copyright © 2014 AGA Institute Terms and Conditions

Figure 4 Changes in overall scores on the Japanese version of IBS-QOL from baseline to week 4. ***P < .001 compared with placebo. Clinical Gastroenterology and Hepatology 2014 12, 953-959.e4DOI: (10.1016/j.cgh.2013.11.024) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Weekly responder rate of improvement in stool consistency. Line graph: responder rate (%). Error bar: 95% CI. Thin line: placebo group (n = 148). Thick black line: ramosetron group (n = 147). *P < .01, **P < .001, compared with the placebo. P values were calculated by using the χ2 test. Clinical Gastroenterology and Hepatology 2014 12, 953-959.e4DOI: (10.1016/j.cgh.2013.11.024) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 Monthly responder rate of improvement in abnormal bowel habits. Column height: responder rate (%). Error bar: 95% CI. Open column: placebo group (n = 148). Black column: ramosetron group (n = 147). P values were calculated by using the χ2 test. Clinical Gastroenterology and Hepatology 2014 12, 953-959.e4DOI: (10.1016/j.cgh.2013.11.024) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 3 Changes in all subscale scores of the Japanese version of IBS-QOL from baseline to week 4. Column height: the values adjusted by using the baseline value as a covariate. Error bar: 95% CI. Open column: placebo group (n = 148). Black column: ramosetron group (n = 147). *P < .05, **P < .01, ***P < .001, compared with the placebo. P values were calculated by using analysis of covariance, with the treatment groups as a factor and baseline score as a covariate. Clinical Gastroenterology and Hepatology 2014 12, 953-959.e4DOI: (10.1016/j.cgh.2013.11.024) Copyright © 2014 AGA Institute Terms and Conditions