Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy Rosalind J.

Slides:

Advertisements

Similar presentations

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.

Advertisements

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

Winter birth in inner-city asthmatic children is associated with increased food allergen sensitization risk J. Andrew Bird, MD, Julie Wang, MD, Cynthia.

Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy Rosalind J.

Food protein–induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features Hideaki Morita, MD, PhD, Hiroko Suzuki,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Fatty acids, inflammation, and asthma

Anne L. Fuhlbrigge, MD, MS, Seung Jin Bae, MS, MPharm, Scott T

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.

Disparities in allergic disease: Hypersensitivity and social disorders

Anti–IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL- 5 and IL-5 receptor levels Miguel L. Stein, MD, Joyce M. Villanueva,

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Food protein–induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features Hideaki Morita, MD, PhD, Hiroko Suzuki,

Is 9 more than 2 also in allergic airway inflammation?

Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny Meri K. Tulic, BSc, PhD, Megan Hodder,

Fatty acids, inflammation, and asthma

Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City Omar Olmedo, BS, Inge.

Kathleen R. Bartemes, BA, Gail M. Kephart, BS, Stephanie J

RAGE processing in chronic airway conditions: Involvement of Staphylococcus aureus and ECP Koen Van Crombruggen, PhD, Gabriele Holtappels, Natalie De.

Benjamin A. Turturice, BS, Diane R. Gold, MD, MPH, Augusto A

Targeting Fel d 1 to FcγRI induces a novel variation of the TH2 response in subjects with cat allergy Kathryn E. Hulse, BS, Amanda J. Reefer, MS, Victor.

Maternal microchimerism protects against the development of asthma

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

β-Agonist enhances type 2 T-cell survival and accumulation

Reply Journal of Allergy and Clinical Immunology

Mammalian target of rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease Aurélie.

Ovalbumin content of influenza vaccines

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy Piush J. Mandhane, MD, Justina M. Greene, Dip.

Airborne cat allergen reduction in classrooms that use special school clothing or ban pet ownership Anne-Sophie Karlsson, MSc, Berith Andersson, SRN,

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

Peanut T-cell epitope discovery: Ara h 1

Altered metabolic profile in patients with IgE to galactose-alpha-1,3-galactose following in vivo food challenge John W. Steinke, PhD, Shawna L. Pochan,

Maternal asthma and microRNA regulation of soluble HLA-G in the airway

Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: A randomized, double-blind clinical trial Michael Weschta, MD, Dagmar Rimek,

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

Advances in the approach to the patient with food allergy

Geographic variability in childhood asthma prevalence in Chicago

Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms Toby J. Williams, Catherine A. Jones,

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Suzanne Havstad, MA, Ganesa Wegienka, PhD, Edward M

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Sara Paveglio, PhD, MS, Erin Bennett, MS, Kelly L. Hawley, PhD, Adam P

Multigenerational cohorts in patients with asthma and allergy

Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations Gary M. Hunninghake, MD, MPH, Manuel E. Soto-Quirós,

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity Joanne E. Sordillo, ScD, MS, Roxanne.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers Gunda Herberth, PhD, Mario.

Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses Diane R. Gold, MD, MPH,

The role of indoor allergens in chronic allergic disease

Alvaro A. Cruz, MD, Robert M

Contribution of dust mite and cat specific IgE to total IgE: Relevance to asthma prevalence Elizabeth A. Erwin, MD, Eva Rönmark, PhD, Kristin Wickens,

Measles and immunomodulation

Association of obesity with IgE levels and allergy symptoms in children and adolescents: Results from the National Health and Nutrition Examination Survey.

Reply Journal of Allergy and Clinical Immunology

Macrolide antibiotics and asthma treatment

Socioeconomic status and inflammatory processes in childhood asthma: The role of psychological stress Edith Chen, PhD, Margaret D. Hanson, MA, Laurel.

Asthma: The past, future, environment, and costs

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Associations among maternal childhood socioeconomic status, cord blood IgE levels, and repeated wheeze in urban children Michelle J. Sternthal, PhD,

Environmental factors and eosinophilic esophagitis

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood Adnan Custovic, MD, PhD, Lars Soderstrom,

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Presentation transcript:

Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy Rosalind J. Wright, MD, MPH, Patricia Finn, MD, Johanna Paola Contreras, MD, Sheldon Cohen, PhD, Robert O. Wright, MD, MPH, John Staudenmayer, PhD, Matthew Wand, PhD, David Perkins, MD, PhD, Scott T. Weiss, MD, MS, Diane R. Gold, MD, MPH Journal of Allergy and Clinical Immunology Volume 113, Issue 6, Pages 1051-1057 (June 2004) DOI: 10.1016/j.jaci.2004.03.032 Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Plots derived from the linear mixed model formulation of penalized splines with family-specific random intercepts included in the model to allow for within-family correlation of repeated stress measurement. Analysis controls for race, active maternal asthma, and cold status. Proliferation was quantified by the SI, which was defined as the mean thymidine incorporation of the stimulated sample divided by that of the unstimulated sample. The SI was considered to be a binary variable indexed as a high (SI >3) or low (SI ≤3) response. Journal of Allergy and Clinical Immunology 2004 113, 1051-1057DOI: (10.1016/j.jaci.2004.03.032) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Modified box plots representing the distribution of TNF-α and IFN-γ expression in supernatants taken from allergen-stimulated (dust mite [Der f 1] and cockroach [Bla g]) and mitogen-stimulated (PHA) PBMCs stratified by caregiver stress levels. Stress was categorized as greater than (High) or less than (Low) the study population median averaged over the first 2 years of the child's life. The upper and lower bounds on the boxes represent the first and third quartiles (25th and 75th percentile of the sample, respectively), the line within the box denotes the median, the whiskers represent values within 1.5 × quartile 3 (top) or quartile 1 (bottom), and the dots show values outlying this range. The y-axis represents actual values that are log spaced. Journal of Allergy and Clinical Immunology 2004 113, 1051-1057DOI: (10.1016/j.jaci.2004.03.032) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions