Fate of Kmt2b target genes.

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Fate of Kmt2b target genes. Fate of Kmt2b target genes. (A) Clustering of bivalent and monovalent target genes by the relative mRNA expression patterns across spermatogenic stages: primitive spermatogonia (Pri-SG), type-A spermatogonia (A-SG), type-B spermatogonia (B-SG), leptotene spermatocytes (Lep-SC), pachytene spermatocytes (Pac-SC), round spermatids (R-ST) and elongated spermatids (E-ST). Genes were divided in subgroups (Bi-1, n=423; Bi-2, n=329; Mono-1, n=140; Mono-2, n=137; see Materials and Methods for details). Values are absolute RNA-seq expression levels (log2 RPKM). Associated GO categories with example genes are indicated on the right. (B) Example screenshots of Kmt2b-target Bi-1 (left) and Mono-2 (right) genes showing affected H3K4me3. (C) Heat map showing the fate of H3K4me3 at the (Bi-1, Bi-2) and monovalent (Mono-1, Mono-2) genes during spermatogenesis and post-fertilization embryonic development (TSSs±5 kb). Color scales for each dataset were automatically determined by ngs.plot. Shin-ichi Tomizawa et al. Development 2018;145:dev169102 © 2018. Published by The Company of Biologists Ltd