IFNα Induces MDSC Maturation and Loss of Suppressive Function

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Figure 2 Involvement of plasmacytoid dendritic cells

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IFNα Induces MDSC Maturation and Loss of Suppressive Function Tumor Promotion CpG DNA TLR9 IFNα Dendritic Cell Macrophage MDSC Plasmacytoid Dendritic Cell Maturation Sca1 Ly6C F4/80 Endosome Treatment of plasmacytoid dendritic cells with CpG DNA leads to the production of inflammatory cytokines like interferon alpha (IFN-α). IFN-α increases the expression of maturation markers on MDSCs, allowing them to mature and lose immunosuppressive function. Adapted from: Zoglmeier, C. et al. 2011. Clin. Cancer. Res. 17:1765. Initial studies were performed on tumor-bearing mice, utilizing the TLR9 ligand, CpG, to invoke potent anti-tumor responses. TLR9 is present within the cell, located on endosomes. Upon stimulation with IFNα, MDSCs can differentiate into macrophages or dendritic cells. ®