Computed tomographic images from a patient with BRAFL597S-mutant metastatic melanoma responding to therapy with the MEK inhibitor TAK-733. Computed tomographic images from a patient with BRAFL597S-mutant metastatic melanoma responding to therapy with the MEK inhibitor TAK-733. Arrows indicate the tumor in the liver (left) and spleen (right) at baseline (A) and after 4 cycles of treatment (B). Kimberly Brown Dahlman et al. Cancer Discovery 2012;2:791-797 ©2012 by American Association for Cancer Research