Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells Kamani H. Tennekoon, Ph.D., Thampoe.

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Presentation transcript:

Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells Kamani H. Tennekoon, Ph.D., Thampoe Eswaramohan, B.Sc., Eric H. Karunanayake, Ph.D. Fertility and Sterility Volume 88, Issue 1, Pages 193-199 (July 2007) DOI: 10.1016/j.fertnstert.2006.11.115 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Effect of leptin on PRL secretion by cultured rat endometrial stromal cells (A) in response to treatment with different doses of leptin for 24 hours, (B) in response to 1 ng/mL leptin for different lengths of time. Leptin significantly increased PRL secretion in a dose- and a time-dependent manner (repeated measures ANOVA on log transformed data, P<.0001). Prolactin secretion also increased with duration of culture even in the absence of leptin stimulation (repeated measures ANOVA on log transformed data. P<.05). Dunnett’s post-test was used to compare each dose or time point with the control (i.e., medium only or time 0 hours). *P<.05, **P<.01. Tennekoon. Effect of leptin on endometrial secretion of prolactin. Fertil Steril 2007. Fertility and Sterility 2007 88, 193-199DOI: (10.1016/j.fertnstert.2006.11.115) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Effect of leptin on insulin-like growth factor-I (IGF-I) secretion by cultured rat endometrial stromal cells (A) in response to treatment with different doses of leptin for 24 hours, (B) in response to 1 ng/mL leptin for different lengths of time. Leptin did not significantly affect IGF-I secretion, but the IGF-I levels increased with duration of culture (repeated measures ANOVA on log transformed data, P<.05). Dunnett’s post-test was used to compare each time point with the control (i.e., time 0 hours). *P<.05. Tennekoon. Effect of leptin on endometrial secretion of prolactin. Fertil Steril 2007. Fertility and Sterility 2007 88, 193-199DOI: (10.1016/j.fertnstert.2006.11.115) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions