Lazaroid reduces production of IL-8 and IL-1 receptor antagonist in ischemic spinal cord injury Takashi Kunihara, MD, Shigeyuki Sasaki, MD, Norihiko.

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Presentation transcript:

Lazaroid reduces production of IL-8 and IL-1 receptor antagonist in ischemic spinal cord injury Takashi Kunihara, MD, Shigeyuki Sasaki, MD, Norihiko Shiiya, MD, Hiroshi Ishikura, MD, Yo Kawarada, MD, Akihiro Matsukawa, MD, Keishu Yasuda, MD The Annals of Thoracic Surgery Volume 69, Issue 3, Pages 792-798 (March 2000) DOI: 10.1016/S0003-4975(99)01413-7

Fig 1 Changes in plasma interleukin-8 (IL-8) levels at four sampling times. T0 = immediately before aortic cross-clamping (AXC), T1 = 5 minutes before declamping of the aorta, T2 = 5 minutes after declamping of the aorta, and T3 = 1 hour after declamping of the aorta. (For group S [sham operation group], T0 = at the time of exposure of the aorta, T1 = 15 minutes after T0, T2 = 25 minutes after T0, and T3 = 1 hour and 20 minutes after T0). (Group P > group L, group S [∗p < 0.02 by repeated measures ANOVA]; T3 > T0, T1, T2 [†p < 0.05; by paired t-test]). The Annals of Thoracic Surgery 2000 69, 792-798DOI: (10.1016/S0003-4975(99)01413-7)

Fig 2 Changes in plasma interleukin-1 receptor antagonist (IL-1ra) levels at four sampling times. Sampling times as in Figure 1. (Group P > group L [∗p < 0.05 by repeated measures ANOVA]; T3 > T0, T1, T2 (††p < 0.001; by paired t-test]). The Annals of Thoracic Surgery 2000 69, 792-798DOI: (10.1016/S0003-4975(99)01413-7)

Fig 3 Changes in plasma tumor necrosis factor (TNF)-α levels at four sampling times. Sampling times as in Figure 1. (No significant difference was noted among three groups; T2 > T3 [†p < 0.05; by paired t-test]). The Annals of Thoracic Surgery 2000 69, 792-798DOI: (10.1016/S0003-4975(99)01413-7)

Fig 4 IL-8 levels in spinal cord tissue samples measured by the specific ELISA. (Group P > Group L, Group S [∗p < 0.05]). The Annals of Thoracic Surgery 2000 69, 792-798DOI: (10.1016/S0003-4975(99)01413-7)

Fig 5 IL-1ra levels in spinal cord tissue samples measured by the specific ELISA. The Annals of Thoracic Surgery 2000 69, 792-798DOI: (10.1016/S0003-4975(99)01413-7)

Fig 6 TNFα levels in spinal cord tissue samples measured by the specific cytotoxic assay. The Annals of Thoracic Surgery 2000 69, 792-798DOI: (10.1016/S0003-4975(99)01413-7)

Fig 7 Hematoxylin and eosin staining (× 250). (A) Group S (sham operation); (B) group P (saline vehicle-treated rabbits); and (C) group L (lazaroid-treated rabbits). The Annals of Thoracic Surgery 2000 69, 792-798DOI: (10.1016/S0003-4975(99)01413-7)