Body weight, blood glucose, and iron status in STZ-induced type 1 diabetic rats with or without insulin therapy. Body weight, blood glucose, and iron status.

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Body weight, blood glucose, and iron status in STZ-induced type 1 diabetic rats with or without insulin therapy. Body weight, blood glucose, and iron status in STZ-induced type 1 diabetic rats with or without insulin therapy. A and B: Sprague-Dawley rats (160–180 g) received intraperitoneal injection of STZ (75 mg/kg; Sigma-Aldrich) or citrate buffer alone. Body weight was monitored during the whole experiment. Insulin therapy was performed in the last 2 weeks of the experiment. Subcutaneous insulin injection (16 units/kg body weight) was given two times every day at 8:00–10:00 a.m. and p.m., respectively. Blood glucose was measured every 2–3 days during the insulin therapy two times right before the insulin injection, and the average level was determined for further statistical analysis. C: Protein levels of hepatic hepcidin, STAT3, and intestinal Fpn were analyzed by WB. n = 6/group. D: Rats were transferred to metabolic cages in the last week of the experiment. The amounts of food intake and excrement were precisely recorded between 9:00 and 10:00 a.m., and the iron content was analyzed to calculate the apparent intestinal iron absorption. White circles, control group; black circles, STZ group; black squares, STZ+Ins group. n = 6/group. Data are expressed as means ± SEM for three groups of six rats. One-way ANOVA, followed by LSD t and SNK post hoc tests, was performed to analyze differences among the three groups. Repeated-measures ANOVA was performed to estimate the effect of group and time (date) on values obtained during the experiments of metabolic cages. Differences were considered significant at P < 0.05. *Significantly different from controls, P < 0.05; **P < 0.01. Heyang Wang et al. Diabetes 2014;63:1506-1518 ©2014 by American Diabetes Association