Heme Oxygenase 1: Does It Have a Role in Renal Cytoprotection? Aisling E. Courtney, MPhil, MRCP, A. Peter Maxwell, PhD, FRCP  American Journal of Kidney Diseases  Volume 51, Issue 4, Pages 678-690 (April 2008) DOI: 10.1053/j.ajkd.2007.11.033 Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Heme oxygenase–catalyzed degradation of heme. Abbreviations: NADPH, reduced form of NADP; NADP, nicotinamide adenine dinucleotide phosphate; Fe, iron; CO, carbon monoxide. American Journal of Kidney Diseases 2008 51, 678-690DOI: (10.1053/j.ajkd.2007.11.033) Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Schematic representation of human heme oxygenase-1 gene. The regulatory sequence shown is limited to components of the proximal promoter region. Abbreviations: HSE, heat shock element; (GT)n, polymorphic GT repeat sequence; NF-κB, nuclear factor-κB; AP-2, activator protein-2; StRE, stress-responsive element; CdRE, cadmium-response element. The TATA box at the transcription start site is also shown. A more complete illustration of the known transcriptions factors influencing HO-1 expression is available in Sikorski et al1 and Alam and Cook.8 American Journal of Kidney Diseases 2008 51, 678-690DOI: (10.1053/j.ajkd.2007.11.033) Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Induction of heme oxygenase 1 (HO-1) gene expression by multiple mediators of renal injury leading to potential renal cytoprotection. Abbreviation: NF-κB, nuclear factor-κB. American Journal of Kidney Diseases 2008 51, 678-690DOI: (10.1053/j.ajkd.2007.11.033) Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions