Molecular epidemiology of hepatitis B virus in Iran

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Molecular epidemiology of hepatitis B virus in Iran S.R. Mohebbi, S. Amini-Bavil-Olyaee, N. Zali, B. Noorinayer, F. Derakhshan, M. Chiani, M. Rostami Nejad, M.H. Antikchi, F. Sabahi, M.R. Zali Clinical Microbiology and Infection Volume 14, Issue 9, Pages 858-866 (September 2008) DOI: 10.1111/j.1469-0691.2008.02053.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Division of Iranian provinces into five parts on the basis of geographical location. Numbers and percentages of patients in each part are shown. Clinical Microbiology and Infection 2008 14, 858-866DOI: (10.1111/j.1469-0691.2008.02053.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 A phylogenetic tree constructed using the neighbour-joining method, based on two different blocks of the HBV.BCP . preC .C with 731-bp sequences plus partial HBV HBsAg with 355-bp gene sequences taken from 136 HBV Iranian isolates were compared with the corresponding region of 71 reference sequences retrieved from the GenBank database representing all major HBV genotypes and subgenotypes of genotype D. Clinical Microbiology and Infection 2008 14, 858-866DOI: (10.1111/j.1469-0691.2008.02053.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 The nucleotide sequence alignment of the C gene (nucleotides 2078–2174) deduced from the nine GenBank subgenotype D1 strains and the 39 Iranian isolates from this study. Three positions (2080, 2107 and 2167) are linked together in 91.2% of Iranian isolates. If T is located at position 2080, there will be C2107 and T2167 (group D1a). If A/C/G is at position 2080, there will be T at position 2107 and C at position 2167 (group D1b). Clinical Microbiology and Infection 2008 14, 858-866DOI: (10.1111/j.1469-0691.2008.02053.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 4 Alignment of amino acids 99–191 of the partial S amino acid sequence of 43 Iranian isolates. The first (3251) is a wild-type isolate and is depicted in detail. Clinical Microbiology and Infection 2008 14, 858-866DOI: (10.1111/j.1469-0691.2008.02053.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions