Correlation between muscle Hsp-72 mRNA expression and rates of glucose and lipid turnover, as determined in protocol 2 (n = 36). Correlation between muscle.

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Philip J. Barter, et al. Circulation 2011;124:

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Presentation transcript:

Correlation between muscle Hsp-72 mRNA expression and rates of glucose and lipid turnover, as determined in protocol 2 (n = 36). Correlation between muscle Hsp-72 mRNA expression and rates of glucose and lipid turnover, as determined in protocol 2 (n = 36). All of the values are expressed as milligrams per kilogram FFM per minute. ○, control subjects; ▵, nondiabetic twins; ⧫, twins with type 2 diabetes. A: Insulin-stimulated total glucose uptake (RdI): control subjects: R = 0.531, P = 0.078 NS; nondiabetic subjects: R = 0.581, P = 0.0053; twins: R = 0.519, P = 0.0128; twins with type 2 diabetes: R = 0.441, NS. B: Insulin-stimulated glucose oxidation (GoxI): controls: R = 0.364, NS; nondiabetic subjects: R = 0.253, NS; twins: R = 0.564, P = 0.0068; twins with type 2 diabetes: R = 0.594, P = 0.0487. C: Net glycogen synthesis during insulin infusion (GsI): controls: R = 0.322, NS; nondiabetic subjects: R = 0.322, NS; twins: R = 0.514, P = 0.0137; twins with type 2 diabetes: R = 0.487, NS. D: lipid oxidation during insulin infusion (LipoxI): control subjects: R = −0.634, P = 0.0355; nondiabetic subjects: R = −0.425, P = 0.0416; twins: R = −0.389, P = 0.0623 (NS); twins with type 2 diabetes: R = 0.643, P = 0.0329 for. *106 copy/μg total RNA. Istvan Kurucz et al. Diabetes 2002;51:1102-1109 ©2002 by American Diabetes Association