Inhalation challenge testing of latex-sensitive health care workers and the effectiveness of laminar flow HEPA–filtered helmets in reducing rhinoconjunctival.

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Presentation transcript:

Inhalation challenge testing of latex-sensitive health care workers and the effectiveness of laminar flow HEPA–filtered helmets in reducing rhinoconjunctival and asthmatic reactions Nunthaporn Laoprasert, MDa,b, Mark C. Swanson, BAd, Richard T. Jones, BSd, Darrell R. Schroeder, MSc, John W. Yunginger, MDb Journal of Allergy and Clinical Immunology Volume 102, Issue 6, Pages 998-1004 (December 1998) DOI: 10.1016/S0091-6749(98)70338-0 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Latex aeroallergen level (mean ± SD) measured every 15 minutes with a high-volume area sampler during the 60-minute challenge. For calculation of mean and standard deviation, nondetectable aeroallergen levels were assigned a value of 55 ng/m3 . For vinyl gloves (challenge 1) and powder-free latex gloves (challenge 2), the sample size is 9 at all time periods. For powdered latex gloves (challenges 3 to 7) the sample size is 44, 44, 40, 37, and 35 at baseline, 15, 30, 45, and 60 minutes, respectively. Journal of Allergy and Clinical Immunology 1998 102, 998-1004DOI: (10.1016/S0091-6749(98)70338-0) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Maximum FEV1 percent change from baseline was calculated for each subject by using the lowest FEV1 measured during the 60-minute challenge period. the distributions of maximum FEV1 during challenges 5 and 6 (powdered latex gloves with HEPA filter removed) were significantly greater than those for challenges 3 and 4 (powdered latex gloves with HEPA filter in place) (P = .030, repeated measures ANOVA). Journal of Allergy and Clinical Immunology 1998 102, 998-1004DOI: (10.1016/S0091-6749(98)70338-0) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Maximum FEV1 percent change from baseline for each subject during challenges 5, 6, and 7 according to cumulative inhaled allergen dose. Maximum FEV1 percent change from baseline was calculated for each subject by using the lowest FEV1 measured during the 60-minute challenge period. The 3 challenge results for each patient are connected by lines. Journal of Allergy and Clinical Immunology 1998 102, 998-1004DOI: (10.1016/S0091-6749(98)70338-0) Copyright © 1998 Mosby, Inc. Terms and Conditions