Charles R. Bridges, MD, James M

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Global cardiac-specific transgene expression using cardiopulmonary bypass with cardiac isolation Charles R. Bridges, MD, James M. Burkman, MD, Ramin Malekan, MD, Stephane M. Konig, MD, Haiyan Chen, MD, Charles B. Yarnall, BS, Timothy J. Gardner, MD, Alan S. Stewart, MD, Mark M. Stecker, MD, PhD, Terry Patterson, PhD, Hansell H. Stedman, MD The Annals of Thoracic Surgery Volume 73, Issue 6, Pages 1939-1946 (June 2002) DOI: 10.1016/S0003-4975(02)03509-9

Fig 1 Open chest canine preparation during cardiopulmonary bypass. Illustrated are all important components of the cardiac isolation scheme including the aortic cross-clamp, superior vena cava (SVC) and inferior vena cava (IVC) cannulae, SVC and IVC snares, pulmonary cross-clamp, cardiac arterial in-flow, and right ventricular (RV) and left ventricular (LV) vent catheters. The Annals of Thoracic Surgery 2002 73, 1939-1946DOI: (10.1016/S0003-4975(02)03509-9)

Fig 2 Evans blue dye-labeled albumin fluorescence histochemistry: cross sections obtained from the diaphragm (A, 200×; B, 40×), left ventricle (C, 100×), and right ventricle (D, 100×). The Annals of Thoracic Surgery 2002 73, 1939-1946DOI: (10.1016/S0003-4975(02)03509-9)

Fig 3 Gene transfer into right ventricular (RV) cardiomyocytes after cardiopulmonary bypass with isolated perfusion of the cardiac circulation in vivo with AdCMVLacZ. (A) RV outflow tract, 100×; (B) RV free wall, 40×; (C) RV outflow tract, 200×; (D) RV free wall, 40×, after infusion of 4 × 1011 particles of AdCMVLacZ and staining with X-Gal 1 week postoperatively. The Annals of Thoracic Surgery 2002 73, 1939-1946DOI: (10.1016/S0003-4975(02)03509-9)

Fig 4 Gene transfer into left ventricular (LV) cardiomyocytes after cardiopulmonary bypass with isolated perfusion of the cardiac circulation in vivo with AdCMVLacZ. (A) LV apex, 100×; (B) LV anterior wall, 100×; (C) LV lateral wall, 100×; (D) intraventricular septum, 100×, after infusion of 4 × 1011 particles of AdCMVLacZ and staining with X-Gal 1 week postoperatively. The Annals of Thoracic Surgery 2002 73, 1939-1946DOI: (10.1016/S0003-4975(02)03509-9)

Fig 5 Gene transfer into left (LV) and right (RV) ventricular cardiomyocytes after cardiopulmonary bypass with isolated perfusion of the cardiac circulation in vivo with AdCMVLacZ. (A) LV endocardium, 40×; (B) RV, adjacent to a large artery and vein, 40×; (C) LV region remote from blood vessels, 40×; (D) RV region remote from blood vessels, 40×, after infusion of 4 × 1011 particles of AdCMVLacZ and staining with X-Gal 1 week postoperatively. The Annals of Thoracic Surgery 2002 73, 1939-1946DOI: (10.1016/S0003-4975(02)03509-9)

Fig 6 β-Galactosidase activities in the heart, liver, and lung (relative light units [RLU]/μg/103, mean ± S.E.M.). (LV = left ventricle; RV = right ventricle.) The Annals of Thoracic Surgery 2002 73, 1939-1946DOI: (10.1016/S0003-4975(02)03509-9)