Human Treg Classes Balance Immunosuppression

Slides:

Advertisements

Similar presentations

José Pedro Lopes Exhausted CD3 CD8 TCR TIM3 1B11 LAG3 Generated in chronic antigen- mediated TCR stimulation. Express inhibitory receptors and lack effector.

Advertisements

Immune dysfunction & its consequences

Regulatory T-cells and Autoimmunity Uma Chandrasekaran Graduate Student, Medical College of Georgia Bits Embryo Lecture.

Contact Information: Tel:

The four major subsets of CD4 T cells Angelika Schmidt Defense against intracellular viruses and bacteria Autoimmunity Th1 Defense against extracellular.

Side Scatter Forward Scatter Lineage CD1c CD141 CD303 lineage negative

Transcription Factor Ets-1 Negatively Regulates

Flow cytometry plot gated on human CD4 T cells

Chronic immune activation in HIV associated Non Hodgkin lymphoma and the effect of antiretroviral therapy Brian Flepisi University of the Western Cape.

Immune Tolerance Kyeong Cheon Jung Department of Pathology

Foxp3 induction dependent on cell cycle progression in vitro.

Regulatory T cells in allergic diseases

Chapter 9 T-cell Development

Immunological Tolerance

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Figure 1 Induction of immune tolerance

CD39: A new surface marker of mouse regulatory γδ T cells

T regulatory cells turn on T regulatory cells

Anti–4-1BB/PD-1 combination enriched CD8+ T cells in TILs

Regulatory T Cells Stay on Course

Volume 17, Issue 6, (December 2002)

Schematic diagram outlining the antitumor activity and abscopal effect in combining checkpoint inhibitors with radiation-induced immune response. Schematic.

Distinct functions of CTLA-4 at different stages of immunity

Treg's Alter Ego: An Accessory in Tumor Killing

Nat. Rev. Rheumatol. doi: /nrrheum

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells by Ellen J. Wehrens, Gerdien.

Tailor-Made Renal Cell Carcinoma Vaccines

Checks and Balances: IL-23 in the Intestine

Activated glycoprotein A repetitions predominant (GARP)–expressing regulatory T cells inhibit allergen-induced intestinal inflammation in humanized mice

Plasticity of CD4+ T Cell Lineage Differentiation

Metabolic control of regulatory T cell development and function

Regulatory T-cell directed therapies in liver diseases

Figure 1 The role of CTLA4 and PD1 in T cell activation

rSema4A potentiates Treg cells in CD4+ T cell cultures.

Exposure to rSema4A increases Treg cell numbers in human PBMC in vitro cultures. Exposure to rSema4A increases Treg cell numbers in human PBMC in vitro.

A Rogue Foxp3 Mutant Undermines Treg Cell Function

Impaired development of Treg cell function upon overexpression of FOXP3A384T in naïve CD4+CD25− T cells. Impaired development of Treg cell function upon.

Volume 53, Issue 4, Pages (October 2010)

Low-dose cyclophosphamide (Cy) reduces intratumoral Treg numbers and promotes enhanced T-cell trafficking and activation within the tertiary lymphoid aggregates.

Regulatory T Cells Stay on Course

Nat. Rev. Nephrol. doi: /nrneph

Immunologic Resolution of Human Chronic Graft-versus-Host Disease

Fig. 4. Analysis of T cell responses according to treatment and in peptide-treated C-peptide responders and nonresponders. Analysis of T cell responses.

Volume 30, Issue 6, Pages (June 2009)

Figure 1 Schematic overview of flow cytometry Schematic overview on the analysis of peripheral immune cells by flow cytometry. Schematic overview of flow.

Immunology Dr. Refif S. Al-Shawk

T-Regulating Hair Follicle Stem Cells

Driving Rel-iant Tregs toward an Identity Crisis

Discordant expression of Foxp3 in induced Tregs.

Figure 3 Underlying mechanisms of TREG cells in atherosclerosis

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

IL-6 neutralization results in induction of CD161+ FOXP3+ CD127– Tregs in EC–CD4+ T cell cocultures. IL-6 neutralization results in induction of CD161+

Figure 1 Distinct cognitive performers present differences in the cell populations of the adaptive immune systemThe profile (cell counts per mL of blood)

Meet the Ikaros Family IL-2 Helios CD103 GITR Naïve CD4+ T cell

Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. Expression of transgenic IGF-1Ea propeptide in the skin increases.

Katie Frith, MD, Anne-Laure Joly, PhD, Cindy S. Ma, PhD, Stuart G

CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A)

CHL cell lines induce a suppressive Treg phenotype in cocultured CD4+ T cells. cHL cell lines induce a suppressive Treg phenotype in cocultured CD4+ T.

Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

Schematic model of the mechanism of Tak1 protection of HSPC survival.

Anti-PD-1H Antibody Prevents Graft Versus Host Disease

Fig. 2 Phenotypic analyses of Bcl11b-deficient Treg cells.

At 17, In-10's Passion Need Not Inflame

Intratumoral lymphoid aggregates are sites of postvaccination T-cell activation and regulation. Intratumoral lymphoid aggregates are sites of postvaccination.

Fig. 5 The regulatory and functional properties of RECs.

Patient Tregs express normal levels of suppression.

Memory phenotypes PBMC-derived MERS-CoV-specific T cells from CWs

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

Comparison of MLTC responses to tumor/peptide stimuli at day 18 and day 34 of growth. Comparison of MLTC responses to tumor/peptide stimuli at day 18 and.

Presentation transcript:

Human Treg Classes Balance Immunosuppression Resting Tregs (rTregs), Activated Tregs (aTregs), and non Tregs are identified by the expression level of specific cell markers (CD45RA, Foxp3, CD4). rTregs, when stimulated, can increase Foxp3 expression, convert to an aTreg, and proliferate. Several mechanisms prevent the excessive accumulation of aTregs. Adapted from: Miyara M., et al. 2011. Autoimmun. Rev. 10:744. As mouse and human markers for Tregs can differ, the CD45RA marker is used in conjunction with Foxp3 to denote 3 distinct human Treg populations. Treg phenotypes are: rTregs (CD45RA+, Foxp3lo, and CD4+); aTregs (CD45RA-, Foxp3high, and CD4+); Non Tregs (CD45RA-, Foxp3lo, and CD4+). There are a number of methods that prevent aTregs from continuously suppressing immune responses. These methods include the rapid death of aTregs following activation and the negative feedback loop of aTregs preventing the conversion of additional rTregs to aTregs. Non Tregs have a propensity of expressing Th17 related factors. ®