Fertility and Sterility Differences in the implantation rates of rat embryos developed in vivo and in vitro: possible role for plasminogen activators  Eliahu D Aflalo, Ph.D., Uriel A Sod-Moriah, Ph.D., Gad Potashnik, M.D., Iris Har-Vardi, Ph.D.  Fertility and Sterility  Volume 81, Pages 780-785 (March 2004) DOI: 10.1016/j.fertnstert.2003.10.014

FIGURE 1 Percentage of implanted embryos in contralateral uterine horn of 17 pseudopregnant rats into which five in vivo- or in vitro-developed blastocysts were transferred (mean ± SEM). Numbers in parentheses are numbers of implanted embryos per transferred blastocysts. P<.01, paired t-test. Aflalo. PA activity in rat embryo implantation.Fertil Steril 2004. Fertility and Sterility 2004 81, 780-785DOI: (10.1016/j.fertnstert.2003.10.014)

FIGURE 2 Endometrial uPA and tPA activity on days 1–5 of pregnancy. Different letters represent significant differences (analysis of variance followed by least significant difference test, P<.01). Aflalo. PA activity in rat embryo implantation.Fertil Steril 2004. Fertility and Sterility 2004 81, 780-785DOI: (10.1016/j.fertnstert.2003.10.014)

FIGURE 3 Activity of tPA in preimplantation embryos developed in vivo and in vitro (means ± SEM). Different letters represent significant differences (analysis of variance followed by least significant difference test, P<.01). Aflalo. PA activity in rat embryo implantation.Fertil Steril 2004. Fertility and Sterility 2004 81, 780-785DOI: (10.1016/j.fertnstert.2003.10.014)

FIGURE 4 Activity of uPA in preimplantation embryos developed in vivo and in vitro (means ± SEM). Different letters represent significant differences (analysis of variance followed by least significant difference test, P<.01). Aflalo. PA activity in rat embryo implantation.Fertil Steril 2004. Fertility and Sterility 2004 81, 780-785DOI: (10.1016/j.fertnstert.2003.10.014)