The Complement System Is Activated in a Biphasic Pattern After Coronary Artery Bypass Grafting Cornelia Hoedemaekers, MD, PhD, Marcel van Deuren, MD,

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The Complement System Is Activated in a Biphasic Pattern After Coronary Artery Bypass Grafting Cornelia Hoedemaekers, MD, PhD, Marcel van Deuren, MD, PhD, Tom Sprong, MD, PhD, Peter Pickkers, MD, PhD, Tom-Eirik Mollnes, MD, PhD, Ina Klasen, MD, PhD, Johannes van der Hoeven, MD, PhD The Annals of Thoracic Surgery Volume 89, Issue 3, Pages 710-716 (March 2010) DOI: 10.1016/j.athoracsur.2009.11.049 Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Terminal complement complex (TCC) and C3bc concentrations in plasma after admission to the intensive care unit (ICU). Values are expressed as arbitrary units per milliliter of plasma. Points represent mean values ± standard error of the mean. The Annals of Thoracic Surgery 2010 89, 710-716DOI: (10.1016/j.athoracsur.2009.11.049) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Changes as a function of time after admission to the intensive care unit (ICU) of C1rs-C1inh (classical pathway activation) (A), C4bc (combined classical and lectin pathway) (B), C3bBbP (alternative pathway activation) (C), and mannose-binding lectin (MBL; lectin pathway) (D) concentrations in plasma. Values are expressed as arbitrary units per milliliter or milligrams per milliliter of plasma. Points represent mean values ± standard error of the mean. The Annals of Thoracic Surgery 2010 89, 710-716DOI: (10.1016/j.athoracsur.2009.11.049) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Concentrations of C3bc (A) and terminal complement complex (TCC) (B) in plasma in patients with low C3bc values compared with patients with normal C3bc concentrations as a function of time after admission to the intensive care unit (ICU). Values are expressed as arbitrary units per milliliter of plasma. Points represent mean values ± standard error of the mean. The Annals of Thoracic Surgery 2010 89, 710-716DOI: (10.1016/j.athoracsur.2009.11.049) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Concentrations of C4bc (A) and C1rs-C1inh (B) in plasma in patients with low C3bc values compared with patients with normal C3bc concentrations as a function of time after admission to the intensive care unit (ICU). Values are expressed as arbitrary units per milliliter of plasma. Points represent mean values ± standard error of the mean. The Annals of Thoracic Surgery 2010 89, 710-716DOI: (10.1016/j.athoracsur.2009.11.049) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions